Document Detail


Recurrent orthostatic global amnesia in a patient with postoperative hyperfibrinogenemia.
MedLine Citation:
PMID:  18589346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transient global amnesia (TGA) is characterized by sudden, temporary dysfunction of antegrade and recent retrograde memory without other neurologic deficits. Although there is sometimes a precipitating event, the origin of TGA remains controversial. We encountered a patient who developed recurrent TGA when upright, in whom the symptom promptly and regularly resolved when supine. Symptoms began about a week after cardiac surgery concurrent with marked hyperfibrinogenemia and acceleration of the erythrocyte sedimentation rate, and abated without recurrence when these laboratory abnormalities were ameliorated by anticoagulant and corticosteroid therapy. Diagnostic studies, including temporal artery biopsy and cerebral angiography, disclosed no anatomic vascular pathology. This is the first report of TGA associated with postoperative inflammation in which amnesia was provoked by orthostatic positioning. In conclusion, these observations implicate ischemia caused by hemodynamic vascular insufficiency as a possible cause of TGA.
Authors:
Brett A Sealove; Louis M Aledort; Charles B Stacy; Jonathan L Halperin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  17     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-3     Citation Subset:  IM    
Affiliation:
Mount Sinai School of Medicine, New York, New York 10029, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Aged
Amnesia, Transient Global / blood,  drug therapy,  etiology*
Anticoagulants / therapeutic use
Aortic Valve Stenosis / complications,  surgery
Bioprosthesis*
Blood Sedimentation
Coronary Artery Bypass*
Dizziness*
Fibrinogen / analysis*
Heart Valve Prosthesis Implantation*
Humans
Male
Myocardial Infarction / complications,  surgery
Optic Neuropathy, Ischemic / complications
Postoperative Complications / blood,  drug therapy,  etiology*
Recurrence
Supine Position
Tachycardia, Supraventricular / complications
Thrombophilia / blood,  complications*
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anticoagulants; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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