Document Detail

Recurrent neonatal herpes presenting initially with hoarseness.
MedLine Citation:
PMID:  2730736     Owner:  NLM     Status:  MEDLINE    
This report describes a newborn with recurrent herpes simplex meningoencephalitis despite vigorous antiviral therapy. The course is unusual in that the presenting symptom was hoarseness. Despite probable adequate acyclovir levels in the spinal fluid, a second episode or progression of herpetic encephalitis occurred, suggesting impairment of host defenses, particularly cellular immunity. This episode was treated with both acyclovir and vidarabine. Pharmacokinetics of the antiviral therapy and immune responses are discussed.
J C Opitz; M A Kettrick; B J Sullivan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  6     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-07-27     Completed Date:  1989-07-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-9     Citation Subset:  IM    
Department of Pediatrics, Marshfield Clinic, Wisconsin 54449.
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MeSH Terms
Acyclovir / pharmacokinetics,  therapeutic use
Herpes Simplex / complications*,  drug therapy
Hoarseness / etiology*
Infant, Newborn
Meningoencephalitis / etiology*
Vidarabine / therapeutic use
Reg. No./Substance:
5536-17-4/Vidarabine; 59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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