Document Detail

Recurrent miscarriage.
MedLine Citation:
PMID:  15921544     Owner:  NLM     Status:  MEDLINE    
Recurrent miscarriage, the occurrence of three consecutive first-trimester losses of pregnancy, affects 1% of women. The purported causes of recurrent miscarriage include chromosomal abnormalities, thrombophilia, metabolic disorders, anatomical causes and immune factors. At present, the only recommended investigations are testing for lupus anticoagulant and anticardiolipin antibody levels (to diagnose antiphospholipid syndrome, an acquired thrombophilia) and the karyotyping of both parents for chromosomal abnormalities. Women with antiphospholipid syndrome should be offered treatment with aspirin and low molecular weight heparin. Couples with chromosomal abnormalities should be referred to a clinical geneticist with whom the options of prenatal diagnosis, pre-implantation genetic diagnosis, donor gametes and adoption in subsequent pregnancies should be discussed. Couples with unexplained recurrent miscarriage should be offered appropriate emotional support and reassurance that they have a good prognosis for future pregnancies.
Andrew W Horne; Claire I Alexander
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of family planning and reproductive health care / Faculty of Family Planning & Reproductive Health Care, Royal College of Obstetricians & Gynaecologists     Volume:  31     ISSN:  1471-1893     ISO Abbreviation:  J Fam Plann Reprod Health Care     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2005-09-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  101087687     Medline TA:  J Fam Plann Reprod Health Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  IM    
Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK.
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MeSH Terms
Abortion, Habitual / etiology*,  genetics,  prevention & control*
Antiphospholipid Syndrome / complications,  immunology
Chromosome Aberrations
Life Style
Pregnancy Complications / immunology
Pregnancy Outcome
Thrombophilia / complications
Uterine Cervical Incompetence / diagnosis
Uterus / abnormalities

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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