Document Detail


Recurrent miscarriage is associated with a family history of ischaemic heart disease: a retrospective cohort study.
MedLine Citation:
PMID:  21244619     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Please cite this paper as: Smith G, Wood A, Pell J, Hattie J. Recurrent miscarriage is associated with a family history of ischaemic heart disease: a retrospective cohort study. BJOG 2011; DOI: 10.1111/j.1471-0528.2010.02890.x. Objective  To determine whether women experiencing recurrent miscarriage were more likely to have a family history of cardiovascular disease. Design  Retrospective cohort study. Setting  Women having a first birth in Scotland between 1992 and 2006. Sample  A total of 74 730 first births were linked to the hospital admission and death certification data for the women's parents through the women's birth certificates. Methods  The incidence of cardiovascular disease in the women's parents was related to the number of miscarriages experienced before their daughters' first births using a Cox proportional hazards model. Main outcome measures  Death or hospital admission of the women's parents for ischaemic heart disease (IHD), cerebrovascular disease (CVD) or venous thromboembolism (VTE). Main results  There was an increased incidence of IHD in the parents of women who experienced two miscarriages before their first birth (hazard ratio 1.25, 95% CI 1.04-1.49) and parents of women who experienced three or more miscarriages before their first birth (hazard ratio 1.56, 95% CI 1.14-2.15). Adjustment for the characteristics of the women at the time of the first birth was without material effect. There was no significant association between miscarriage and family history of CVD or VTE. There was no significant association between the number of therapeutic terminations of pregnancy before the first birth and the incidence of any type of cardiovascular disease in the women's parents. Conclusions  The parents of women who experience recurrent miscarriage are more likely to experience IHD. Recurrent miscarriage and IHD may have common patho-physiological pathways and genetic predispositions.
Authors:
Gcs Smith; Am Wood; Jp Pell; J Hattie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-19
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  -     ISSN:  1471-0528     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors Journal compilation © RCOG 2011 BJOG An International Journal of Obstetrics and Gynaecology.
Affiliation:
 Department of Obstetrics and Gynaecology and  Department of Public Health and Primary Care, Cambridge University, Cambridge, UK  Public Health Section, University of Glasgow, Glasgow, UK  Information Services Division, NHS National Services Scotland, Edinburgh, UK.
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