Document Detail


Recurrent ischemic stroke in a patient with idiopathic thrombocytopenic purpura.
MedLine Citation:
PMID:  19949967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recurrent cerebral infarctions developed in a patient with idiopathic thrombocytopenic purpura (ITP). At the time of the first stroke, there were large thrombi in the right proximal internal carotid artery (ICA) and an occlusion of the right terminal ICA. The occlusion was recanalized by intra-arterial infusion of urokinase. After 20 months, he suffered another ischemic attack. The autoantibodies in ITP directed against antigens presented on both platelets and endothelial cells might induce the endothelial damage, thrombus formation, and embolic occlusion of the artery.
Authors:
Hak Young Rhee; Hye-Yeon Choi; Sang-Beom Kim; Won-Chul Shin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  30     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
Affiliation:
Department of Neurology, Kyung Hee University East-West Neo Medical Center, Kyunghee Univ #149, Sangil-dong, Gangdong-gu, Seoul, South Korea. azzo73@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticoagulants / administration & dosage
Autoantibodies / blood
Brain Ischemia / diagnosis,  drug therapy,  etiology*,  immunology
Cerebral Angiography
Diffusion Magnetic Resonance Imaging
Fibrinolytic Agents / administration & dosage
Heparin / administration & dosage
Humans
Intracranial Thrombosis / diagnosis,  drug therapy,  etiology*,  immunology
Male
Purpura, Thrombocytopenic, Idiopathic / complications*,  diagnosis,  drug therapy,  immunology
Recurrence
Stroke / diagnosis,  drug therapy,  etiology*,  immunology
Thrombolytic Therapy
Treatment Outcome
Urokinase-Type Plasminogen Activator / administration & dosage
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Autoantibodies; 0/Fibrinolytic Agents; 9005-49-6/Heparin; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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