Document Detail


Recurrent ischaemia during continuous multilead ST-segment monitoring identifies patients with acute coronary syndromes at high risk of adverse cardiac events; meta-analysis of three studies involving 995 patients.
MedLine Citation:
PMID:  11603907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Recurrent ischaemia, detected by continuous ECG monitoring, in patients with unstable angina increases the risk of unfavourable outcome. Studies that evaluated this relationship have been limited by the small series of patients. By combining data from three studies, the present analysis aims to provide an accurate assessment of the impact of recurrent ischaemia detected by multilead ECG-ischaemia monitoring on the occurrence of death and myocardial infarction in patients with acute coronary syndromes. METHODS AND RESULTS: Data were obtained from CAPTURE, PURSUIT and FROST, three trials evaluating glycoprotein IIb/IIIa blockers in patients with non-ST-elevation acute coronary syndromes. Patients were monitored for 24 h after enrollment with a computer-assisted 12-lead or a vectorcardiographic ECG-ischaemia monitoring device. In a retrospective blinded analysis, recurrent ischaemic episodes were identified by a computer algorithm. The number of ischaemic episodes was normalized to 24 h. Ischaemic episodes were detected in 271 (27%) of 995 patients. There was a direct proportional relationship between the number of ischaemic episodes per 24 h and the probability of cardiac events at 5 and 30 days. The 30-day composite of death and myocardial infarction occurred in 5.7% of patients without episodes and increased to 19.7% in patients with >/=5 episodes. After adjustment for baseline predictors of adverse outcome, the relative risk of death or myocardial infarction at 5 and 30 days increased by 25% for each additional ischaemic episode per 24 h. CONCLUSIONS: This analysis emphasizes the need for integration of multilead ECG-ischaemia monitoring systems in coronary care units and emergency wards to improve early risk stratification in patients with acute coronary syndromes.
Authors:
K M Akkerhuis; P A Klootwijk; W Lindeboom; V A Umans; S Meij; P P Kint; M L Simoons
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  European heart journal     Volume:  22     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-17     Completed Date:  2002-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1997-2006     Citation Subset:  IM    
Copyright Information:
Copyright 2001 The European Society of Cardiology.
Affiliation:
The Thoraxcenter, University Hospital Rotterdam, Room H-543, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Angina, Unstable / complications*,  mortality,  prevention & control
Cause of Death
Coronary Disease / etiology,  mortality,  prevention & control
Electrocardiography
Female
Humans
Male
Middle Aged
Monitoring, Physiologic
Myocardial Ischemia / etiology*,  mortality,  prevention & control
Prognosis
Recurrence / prevention & control
Comments/Corrections
Comment In:
Eur Heart J. 2001 Nov;22(21):1972-3   [PMID:  11603903 ]

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