Document Detail


Recurrent inhibition in motor systems, a comparative analysis.
MedLine Citation:
PMID:  24866823     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The review proposes a comparison between recurrent inhibition in motor systems of vertebrates and the leech nervous system, where a detailed cellular and functional analysis has been accomplished. A comparative study shows that recurrent inhibition is a conserved property in motor systems of phylogenetically distant species. Recurrent inhibition has been extensively characterized in the spinal cord of mammals, where Renshaw cells receive excitatory synaptic inputs from motoneurons (MNs) and, in turn, exert an inhibitory effect on the MNs. In the leech, a recurrent inhibitory circuit has been described, centered around a pair of nonspiking (NS) neurons. NS are linked to every excitatory MN through rectifying electrical junctions. And, in addition, the MNs are linked to the NS neurons through hyperpolarizing chemical synapses. Functional analysis of this leech circuit showed that heteronymous MNs in the leech are electrically coupled and this coupling is modulated by the membrane potential of NS neurons. Like Renshaw cells, the membrane potential of NS neurons oscillates in phase with rhythmic motor patterns. Functional analysis performed in the leech shows that NS influences the activity of MNs in the course of crawling suggesting that the recurrent inhibitory circuit modulates the motor performance.
Authors:
Lidia Szczupak
Related Documents :
24305053 - Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical pe...
24922073 - Dyrk1a promotes dopaminergic neuron survival in the developing brain and in a mouse mod...
19403813 - Feature-dependent sensitive periods in the development of complex sound representation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-24
Journal Detail:
Title:  Journal of physiology, Paris     Volume:  -     ISSN:  1769-7115     ISO Abbreviation:  J. Physiol. Paris     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9309351     Medline TA:  J Physiol Paris     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Two-Photon-Responsive Supramolecular Hydrogel for Controlling Materials Motion in Micrometer Space.
Next Document:  Surgery for a giant arteriovenous malformation without motor deterioration: preoperative transcrania...