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Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma.
MedLine Citation:
PMID:  23047306     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In eukaryotic cells, DNA is packaged into chromatin and this compact storage in the nucleus promotes transcriptional repression of genes. Chromatin remodeling complexes such as the SWI/SNF complex are involved in making DNA accessible to transcription factors and thereby are implicated in the regulation of gene expression. Mutations and altered expression of chromatin remodeling complex genes have been described in cancer cells. Indeed, non-small cell lung cancer cell lines have been shown to harbor mutations in SMARCA4 (BRG1) a member of the SWI/SNF complex, but evidence has been less clear in primary tumors. Recently inactivating mutations in ARID2 were found in liver cancer related to HCV infection and in melanoma. Here, we explored, using a genome wide strategy and subsequent sequencing of targeted genes, whether chromatin remodeling is implicated in primary lung adenocarcinoma. Two genes were individualized from the genome screening as homozygously deleted in a set of samples: JARID2 and ARID2. Subsequent analysis of the entire coding sequences showed that ARID2 loss-of-function mutations were found in 5% of non-small cell lung cancers, thereby constituting one of the most frequently mutated genes in this cancer type after TP53, KRAS, EGFR, CDKN2A and STK11. © 2012 Wiley Periodicals, Inc.
Authors:
Gilles Manceau; Eric Letouzé; Cécile Guichard; Audrey Didelot; Aurelie Cazes; Hélène Corté; Elizabeth Fabre; Karine Pallier; Sandrine Imbeaud; Françoise Le Pimpec-Barthes; Jessica Zucman-Rossi; Pierre Laurent-Puig; Hélène Blons
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-10
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 UICC.
Affiliation:
UMR-S 775 Molecular basis of response to xenobiotics 45 rue des Saints-Pères, 75006 Paris, France.
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