| Recurrent herpes simplex labialis: viral replication and clinical course. | |
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MedLine Citation:
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PMID: 217269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to provide additional information on the clinical course and viral replication kinetics of herpes simplex virus (HSV) in recurrent herpes labialis. Data were obtained on 20 subjects who were followed for five days from the first day of the lesion. HSV was isolated in 17 subjects (85%); 75% were positive on day 1 of the lesion. Median HSV titer on day 1 was 1.7 x 10(3)/0.2ml. Isolation rates and titers dropped sharply and virus could no longer be detected by day 4. The clinical course both in terms of the frequency and the severity of the symptoms paralleled the kinetics of viral replication. Thermography delineated location of subsequent lesions in three early symptomatic patients who were studied at the time when no visible lesions were observed. These data are felt to provide useful background information for future studies on the efficacy of topical antiviral agents. |
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Authors:
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M W Rytel; R A Niebojewski; F G Aguilar-Torres; T J Russell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 276 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1978 Nov-Dec |
Date Detail:
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Created Date: 1979-04-28 Completed Date: 1979-04-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 319-23 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Female Herpes Labialis / microbiology* Humans Male Recurrence Simplexvirus / isolation & purification Thermography Time Factors Virus Replication* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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