Document Detail

Recurrent hepatocellular carcinoma after hepatic resection: prognostic factors and long-term outcome.
MedLine Citation:
PMID:  15063895     Owner:  NLM     Status:  MEDLINE    
AIM: The prognosis of patients with recurrent hepatocellular carcinoma (HCC) after hepatic resection varies widely. This study analyzed long-term survival and prognostic factors of patients with recurrent HCC after hepatectomy. METHODS: From July 1991 to December 2000, 623 patients underwent hepatic resection for HCC. Of those, 347 (56.5%) patients had tumour recurrence, and 286 patients with follow-up time more than 24 months after recurrence were enrolled. Twenty-seven clinicopathologic factors underwent both univariate and multivariate analysis. RESULTS: Of these 286 patients, survival times after tumour recurrence were mean 672+/-619 days; median 468 days; and, range 10-3753 days. The overall 1-, 3-, 5-, and 10-year post-recurrence survival rates were 61.5, 33.4, 18.2, and 9.0%, respectively. Seventy (24.5%) patients were alive at the time of study, and 10 of the 34 patients who underwent re-resection were disease-free. By Cox regression analysis, multiple initial tumours (relative risk (RR) 1.428), recurrent multiple (RR 1.372), extrahepatic recurrence (RR 2.434), recurrent tumour size >2 cm (RR 1.926), post-hepatectomy period until recurrence <1 year (RR 1.769), and non-resectional treatment of recurrent tumours (RR 3.527) were independent prognostic factors for post-recurrent survival rates. CONCLUSIONS: In patients with recurrent HCC after hepatectomy, both initial and recurrent tumour factors influenced their prognosis. Early detection of recurrent tumours is important. Re-resection correlated with better post-recurrent survival rates.
W-T Chen; G-Y Chau; W-Y Lui; S-H Tsay; K-L King; C-C Loong; C-W Wu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology     Volume:  30     ISSN:  0748-7983     ISO Abbreviation:  Eur J Surg Oncol     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-07-15     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  8504356     Medline TA:  Eur J Surg Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  414-20     Citation Subset:  IM    
Department of Surgery, Taipei Veterans General Hospital, College of Medicine, National Yang-Ming University, Shih-pai, Taipei, Taiwan.
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MeSH Terms
Carcinoma, Hepatocellular / mortality,  surgery*
Disease-Free Survival
Follow-Up Studies
Liver Neoplasms / mortality,  surgery*
Middle Aged
Neoplasm Recurrence, Local / mortality*
Survival Analysis
Treatment Outcome

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