Document Detail

Recurrent genomic rearrangements are not at the fragile sites on chromosomes 3 and 5 in human renal cell carcinomas.
MedLine Citation:
PMID:  3417313     Owner:  NLM     Status:  MEDLINE    
It has been suggested that fragile sites on human chromosomes predispose to specific rearrangements seen in cancer. Renal cell carcinoma is characterised by recurrent aberrations of chromosome 3p and frequent rearrangements of chromosome 5q. To investigate whether there might be an association between fragile sites and recurrent breakpoints in renal cell carcinoma, we have determined the breakpoints observed in 50 tumours and compared them to the known fragile sites on chromosomes 3 and 5. No correlation between fragile sites and cancer-related breakpoints in renal cell carcinomas was found.
G Kovacs; P Brusa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  80     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-19     Completed Date:  1988-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Labor für Tumorcytogenetik, Pathologisches Institut, Medizinische Hochschule, Hannover, Federal Republic of Germany.
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MeSH Terms
Carcinoma, Renal Cell / genetics*
Chromosome Fragile Sites
Chromosome Fragility*
Chromosome Mapping
Chromosomes, Human, Pair 3*
Chromosomes, Human, Pair 5*
Kidney Neoplasms / genetics*
Tumor Cells, Cultured

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