Document Detail

Recurrent genital infection in the guinea pig: differences between herpes simplex types 1 and 2.
MedLine Citation:
PMID:  1339184     Owner:  NLM     Status:  MEDLINE    
Recurrence rates of genital infections are significantly higher for herpes simplex virus (HSV) type 2 than HSV type 1. Reasons for this difference are not known. In this report, multiple strains of HSV-1 and HSV-2 were evaluated in the guinea-pig model. HSV-2 strains showed significantly higher genital lesion recurrence than HSV-1, including HSV-1 McKrae strain which is highly recurrent in ocular infections. HSV-2 strains were also associated with more frequent asymptomatic vaginal virus shedding. Further study showed that HSV-1 strains replicated as well as HSV-2 in both the genital tract and the nervous system during acute infection. In addition, no difference was detected between HSV-1 and HSV-2 in nervous system latency. Thus, a number of possible explanations for the observed difference in genital herpes recurrence rates were examined and excluded.
M L Landry; D Myerson; C Bull
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Intervirology     Volume:  34     ISSN:  0300-5526     ISO Abbreviation:  Intervirology     Publication Date:  1992  
Date Detail:
Created Date:  1993-09-17     Completed Date:  1993-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0364265     Medline TA:  Intervirology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  169-79     Citation Subset:  IM    
Virology Reference Laboratory/151B, VA Medical Center, West Haven, CT 06516.
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MeSH Terms
Acute Disease
Genetic Variation
Guinea Pigs
Herpes Genitalis / complications,  microbiology*,  mortality
Nervous System Diseases / complications,  microbiology
Simplexvirus / genetics*,  growth & development
Virus Shedding

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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