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Recurrent fetal loss and antiphospholipid antibodies: clinical and therapeutic aspects.
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MedLine Citation:
PMID:  18476173     Owner:  NLM     Status:  In-Data-Review    
Recurrent fetal losses indicate screening for antiphospholipid antibodies, especially after the third consecutive fetal loss, or when they occur after 12 weeks gestation or when the mother presents with thrombosis or other ailments of antiphospholipid syndrome. Fetal loss may be caused by thromboses of placental vasculature. There is no agreement concerning the mechanism of thromboses: protein C pathway and/or annexin V are the best candidates. When fetal loss occurs early during gestation, murine models suggest that antiphospholipid antibodies can also act on trophoblasts by inhibiting syncytia formation. Among the high risk patients with more than two fetal losses, an association of aspirin and heparin given early during gestation is successful in 70-80% of cases.
O Blétry; A M Piette
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  5     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  1997  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  183-91     Citation Subset:  -    
Service de Médecine Interne Hôpital Foch 40 rue Worth Suresnes 92151 France.
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Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1997 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 1 Month: 10 Year: 1997
Accepted Day: 21 Month: 10 Year: 1997
Print publication date: Year: 1997
Volume: 5 Issue: 2
First Page: 183 Last Page: 191
ID: 2364563
PubMed Id: 18476173
Publisher Item Identifier: S1064744997000288
DOI: 10.1155/S1064744997000288

Recurrent Fetal Loss and Antiphospholipid Antibodies: Clinical and Therapeutic Aspects
O. Bl?try
A.-M. Piette
Service de M?decine InterneH?pital Foch40 rue WorthSuresnes92151France

Article Categories:
  • Research Article

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