Document Detail

Recurrent erythema multiforme triggered by progesterone sensitivity.
MedLine Citation:
PMID:  20849459     Owner:  NLM     Status:  MEDLINE    
Determining the underlying etiology of recurrent erythema multiforme (EM) can be a difficult endeavor. Although infection with herpes simplex virus (HSV) has been implicated in some cases, the precise trigger of a given patient's recurrent EM often remains elusive. We discuss the case of a woman with a recurrent blistering eruption that was clinically and histopathologically consistent with EM. An investigation into the etiology of the patient's EM suggested that HSV was not the causative factor but instead pointed toward a hormonal influence that we interpret as autoimmune progesterone dermatitis (APD). This case is presented to highlight the importance of considering hormonal triggers in women with recurrent EM that consistently flares during the luteal phase of the menstrual cycle, the point at which serum progesterone levels peak. A brief review of the literature regarding the diagnosis, histopathology, etiology and treatment of APD is further provided.
Teresa J Nasabzadeh; Catherine M Stefanato; John E Doole; Arash Radfar; Jag Bhawan; Suraj Venna
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  37     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1164-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons A/S.
Washington Hospital Center, Department of Internal Medicine-Dermatology, 110 Irving Street NW, Washington DC 20010, USA.
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MeSH Terms
Autoimmune Diseases / complications,  pathology
Erythema Multiforme / etiology,  pathology*
Progesterone / adverse effects,  diagnostic use
Young Adult
Reg. No./Substance:
Comment In:
J Cutan Pathol. 2010 Nov;37(11):1130-1   [PMID:  20849455 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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