| Recurrent acute pancreatitis possibly induced by atorvastatin and rosuvastatin. Is statin induced pancreatitis a class effect? | |
| | |
MedLine Citation:
|
PMID: 15536291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
CONTEXT: Few data exist about the incidence of drug-induced pancreatitis in the general population. Drugs are related to the etiology of pancreatitis in about 1.4-2% of cases. While statins are generally well tolerated they have been known to be associated with pancreatitis. Acute pancreatitis has been reported in a few cases treated with atorvastatin, fluvastatin, lovastatin, simvastatin and pravastatin. CASE REPORT: We report the case of a 77-year-old patient who developed acute pancreatitis after treatment with rosuvastatin, which resolved on withdrawal of the medication. She had a similar episode of pancreatitis a year ago precipitated by atorvastatin, which resolved on withdrawal. Extensive workup on both occasions failed to reveal any other etiology for the pancreatitis. CONCLUSION: To our knowledge this is the first report of rosuvastatin-induced pancreatitis. The occurrence of pancreatitis with two different statins in our patient argues that statins induced pancreatitis may be a class-effect of statins. With statin prescriptions on the rise clinicians need to be aware of this complication of statin treatment and remember that the newest statin, rosuvastatin is not dissimilar to the other statins in causing pancreatitis. |
| | |
Authors:
|
Sonal Singh; Amit Nautiyal; James G Dolan |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2004-11-10 |
Journal Detail:
|
Title: JOP : Journal of the pancreas Volume: 5 ISSN: 1590-8577 ISO Abbreviation: JOP Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-11-10 Completed Date: 2005-11-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101091810 Medline TA: JOP Country: Italy |
Other Details:
|
Languages: eng Pagination: 502-4 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Unity Health System, Rochester, NY 14626, USA. ssingh@unityhealth.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Aged Female Fluorobenzenes / adverse effects* Heptanoic Acids / adverse effects* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects* Pancreatitis / chemically induced* Pyrimidines / adverse effects* Pyrroles / adverse effects* Recurrence Sulfonamides / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/Fluorobenzenes; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Pyrroles; 0/Sulfonamides; 110862-48-1/atorvastatin; 287714-41-4/rosuvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pseudocyst formation in gastric ectopic pancreas.
Next Document: Pancreatic pseudopapillary tumor in a male child.