Document Detail


Recurrent abruptio placentae in a cynomolgus monkey (Macaca fascicularis).
MedLine Citation:
PMID:  23398915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Abruptio placentae, defined as premature separation of a normally implanted placenta, is a life threatening pregnancy complication with unknown pathophysiology. A history of abruptio placentae is the major risk factor for this pregnancy complication in humans. We describe the first case of recurrent abruptio placentae in a Macaca fascicularis.
MATERIAL AND METHODS: A pregnant M. fascicularis at term gestation was presented with weakness and hypothermia. Cesarean section revealed retroplacental hemorrhage with partial placental separation from the uterus.
RESULTS: The weight of the female fetus was within the lower birth weight range for these species. The maternal side of placenta contained necrotic tissue, occupying approximately 60% of the maternal surface. The placental implantation bed demonstrated neutrophil infiltration. Perivascular collections of lymphocytes were noticed in the uterine smooth muscle.
CONCLUSION: This case report underlines the importance of neutrophil infiltration and uterine venous drainage in the cascade of events leading to abruptio placentae.
Authors:
N Schlabritz-Loutsevitch; G Hubbard; J Zhang; S Gupta; E Dick
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-09
Journal Detail:
Title:  Placenta     Volume:  34     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-08-29     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  388-90     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Abruptio Placentae / etiology,  veterinary*
Animals
Cesarean Section
Female
Fetal Death / etiology,  veterinary
Macaca fascicularis*
Monkey Diseases*
Neutrophil Infiltration
Pregnancy
Recurrence
Risk Factors
Grant Support
ID/Acronym/Agency:
C06 RR014578/RR/NCRR NIH HHS; C06 RR014578/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; C06 RR015456/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS; P51 RR013986/RR/NCRR NIH HHS
Comments/Corrections

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