| Recurrent ovarian cancer: use of contrast-enhanced CT and PET/CT to accurately localize tumor recurrence and to predict patients' survival. | |
| | |
MedLine Citation:
|
PMID: 20697116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To compare accuracy and interobserver variability in the detection and localization of recurrent ovarian cancer with contrast material-enhanced (CE) computed tomography (CT) and positron emission tomography (PET)/CT and determine whether imaging findings can be used to predict survival. MATERIALS AND METHODS: Waiving informed consent, the institutional review board approved this HIPAA-compliant, retrospective study of 35 women (median age, 54.4 years) with histopathologically proven recurrent ovarian carcinoma who underwent CE CT and PET/CT before exploratory surgery. All CE CT and PET/CT scans were independently analyzed. Tumor presence, number of lesions, and the size and maximum standardized uptake value (SUV(max)) of the largest lesion were recorded for patient and region. Surgical histopathologic findings constituted the reference standard. Areas under the receiver operating characteristic curves (AUCs), κ statistics, and hazard ratios were calculated. RESULTS: Readers' AUCs in detection of recurrence for region were 0.85 (95% confidence interval [CI]: 0.81, 0.90) and 0.78 (95% CI: 0.72, 0.83) for CE CT and 0.84 (95% CI: 0.79, 0.89) and 0.74 (95% CI: 0.67, 0.81) for PET/CT (P = .76); 12 patients died. At PET/CT, size, number, and SUV(max) of peritoneal deposits were significantly associated with poor survival for readers 1 and 2 (P ≤ .01and ≤ .05, respectively), as were long- and short-axis diameters, number, and SUV(max) of distant lymph nodes for reader 1 (P ≤ .001). With CE CT, size (reader 1) and number (readers 1 and 3) of peritoneal deposits were significantly associated with poor survival (P ≤ .01), as were long- and short-axis diameters and number of distant lymph nodes for reader 1 (P ≤ .01). Interobserver agreement ranged from fair (patient, κ = 0.30) to moderate (region, κ = 0.55) for CE CT and fair (patient, κ = 0.24) to substantial (region, κ = 0.63) for PET/CT. CONCLUSION: Preliminary data suggest that CE CT and PET/CT may have similar accuracy in detection of recurrent ovarian cancer. Tumor size, number, and SUV(max) may have potential as prognostic biomarkers for patients with recurrent ovarian cancer. |
| | |
Authors:
|
Evis Sala; Masako Kataoka; Neeta Pandit-Taskar; Nicole Ishill; Svetlana Mironov; Chaya S Moskowitz; Oleg Mironov; Michelle A Collins; Dennis S Chi; Steven Larson; Hedvig Hricak |
Related Documents
:
|
19370346 - Performance of integrated fdg pet/contrast-enhanced ct in the diagnosis of recurrent co... 17207656 - Utility of 2-[18f] fluoro-2-deoxy-d-glucose positron emission tomography and positron e... 17706526 - Staging of lung cancer. 9867146 - Fluorine-18-fluorodeoxyglucose pet identification of cardiac metastasis arising from ut... 12111936 - Validation of diffusion tensor mri-based muscle fiber tracking. 8976956 - Effect of hydration status on renal medulla attenuation on unenhanced ct scans. |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2010-08-09 |
Journal Detail:
|
Title: Radiology Volume: 257 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-20 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 125-34 Citation Subset: AIM; IM |
Affiliation:
|
Department of Radiology, Addenbrooke's Hospital, University of Cambridge, Cambridge, England. es220@radiol.cam.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Area Under Curve Contrast Media / diagnostic use Cross-Sectional Studies Female Humans Lymphatic Metastasis Middle Aged Neoplasm Recurrence, Local / pathology, radiography*, radionuclide imaging* Observer Variation Ovarian Neoplasms / pathology, radiography*, radionuclide imaging*, surgery Positron-Emission Tomography / methods* Predictive Value of Tests Proportional Hazards Models Retrospective Studies Survival Rate Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidentally detected gallbladder polyps: is follow-up necessary?--Long-term clinical and US analysi...
Next Document: Ligaments and plicae of the elbow: normal MR imaging variability in 60 asymptomatic subjects.