Document Detail

Recurrent acute stent thrombosis due to allergic reaction secondary to clopidogrel therapy.
MedLine Citation:
PMID:  20683245     Owner:  NLM     Status:  In-Data-Review    
Despite significant benefits including mortality advantage demonstrated with antiplatelet therapy in large clinical trials, the occurrence of adverse ischemic events, including stent thrombosis after percutaneous coronary intervention has been the challenging and devastating complication. Clopidogrel as a monotherapy, or more common in combination with aspirin, represents a cornerstone of modern pharmacotherapy in the invasive era. Although vigilance in maintenance of this dual antiplatelet treatment is mandatory, obligatory cessation of one of these agents can be observed in rare circumstances of adverse events. We describe a patient who developed recurrent acute stent thrombosis associated with clopidogrel-induced allergic reaction and discuss our therapeutic considerations.
Can Yücel Karabay; Mehmet Mustafa Can; Ibrahim Halil Tanboğa; Güler Ahmet; Atila Bitigen; Victor Serebruany
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of therapeutics     Volume:  18     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e119-22     Citation Subset:  IM    
1Department of Cardiology, Koşuyolu Heart & Research Hospital, Istanbul, Turkey; and 2Department of Cardiology, Johns Hopkins University, Baltimore, MD.
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