Document Detail

Recurrence of renal cell carcinoma more than 5 years after nephrectomy.
MedLine Citation:
PMID:  11972645     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We evaluated clinical features and predictive factors for the recurrence of renal cell carcinoma (RCC) developing more than 5 years after nephrectomy. METHODS: We retrospectively reviewed 239 patients with RCC who underwent surgery for the primary lesion. To identify factors that affected recurrence more than 5 years after nephrectomy (delayed recurrence) and its clinical outcomes, we performed a multivariate analysis using Cox's proportional hazards model and a survival study. RESULTS: Recurrence developing within 5 years after nephrectomy (early recurrence) was found in 57 patients and delayed recurrence in 11 patients. The multivariate analysis revealed no clinical and pathologic features influencing delayed recurrence in 114 patients who survived more than 5 years after nephrectomy without having early recurrence. The patients with delayed recurrence showed better clinical outcomes than those with early recurrence when the rate was determined from the time of recurrence. CONCLUSIONS: Although delayed recurrence is not a rare event for patients with RCC, no clinical and pathologic factors at the time of the initial treatment can predict the recurrence. Patients who are free of recurrence for more than 5 years after surgery for a primary lesion should be carefully followed up for delayed recurrence.
Kohsuke Uchida; Noriomi Miyao; Naoya Masumori; Atsushi Takahashi; Toshiro Oda; Masahiro Yanase; Hiroshi Kitamura; Naoki Itoh; Masaaki Sato; Taiji Tsukamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  9     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2003-03-25     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
Department of Urology (Clinical Pathology Division), Sapporo Medical University School of Medicine, Japan.
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MeSH Terms
Carcinoma, Renal Cell / surgery*
Kidney Neoplasms / pathology*
Middle Aged
Neoplasm Recurrence, Local / epidemiology*
Retrospective Studies
Time Factors

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