Document Detail

Recurrence and regrowth of benign meningiomas.
MedLine Citation:
PMID:  19856217     Owner:  NLM     Status:  MEDLINE    
The World Health Organization (WHO) grading system for meningioma is helpful for predicting aggressive subtypes. However, even benign meningiomas sometimes show relatively rapid growth and may recur after total removal. We attempted to find histopathological features that would be valuable for predicting recurrence or regrowth of WHO grade I meningiomas. We investigated 135 benign meningiomas, of which 120 were totally removed (Simpson's grade I-III). The median follow-up period was 9.7 years (1-21 years). The recurrence rate in the patients with total removal was 7.5% at 10 years and 9.3% at 20 years. The univariate analysis revealed that MIB-1 index (>or=2%), existence of mitosis, absence of calcification, and paucity of fibrosis significantly correlated with recurrence. On the other hand, the histological features of sheet-like growth, prominent nucleoli, and necrosis did not correlate with recurrence, because they were relatively rare in grade I tumors. Multivariate analysis revealed that high MIB-1 index and absence of calcification significantly correlated with recurrence. The patients with recurrent or residual tumors did not always receive adjuvant treatment. Including subtotally treated tumors, the retreatment rate was 9.8% at 10 years and 25.6% at 20 years. MIB-1 index and Simpson's grade significantly correlated with retreatment in both univariate and multivariate analyses.
Satoshi Nakasu; Tadateru Fukami; Jyunya Jito; Kazuhiko Nozaki
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Publication Detail:
Type:  Journal Article     Date:  2009-10-27
Journal Detail:
Title:  Brain tumor pathology     Volume:  26     ISSN:  1861-387X     ISO Abbreviation:  Brain Tumor Pathol     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-26     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716507     Medline TA:  Brain Tumor Pathol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Division of Neurosurgery and Neurooncology, Kusatsu General Hospital, 1660 Yabase, Kusatsu, Shiga, 525-8585, Japan.
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MeSH Terms
Calcinosis / pathology
Fibrosis / pathology
Meningeal Neoplasms / pathology*,  surgery
Meningioma / pathology*,  surgery
Mitotic Index
Neoplasm Recurrence, Local / pathology*,  surgery
Retrospective Studies

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