Document Detail

Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation.
MedLine Citation:
PMID:  10486376     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hepatoblastoma is an exceptional cause of primary malignant liver tumour in the adult. PATIENT: The case is reported of an adult patient transplanted for alcoholic cirrhosis complicated by multifocal hepatocellular carcinoma in whom a recurrence in the form of a mixed hepatoblastoma invading the whole transplanted liver developed three months after liver transplantation. METHODS: Complete clinical, histopathological, and immunohistochemical data were reviewed. RESULTS: The recurrent tumour invaded the whole liver. The major component was a mixed hepatoblastoma, with an epithelial component expressing cytokeratin and a mesenchymal component expressing vimentin. The tumour also contained a minor hepatocarcinomatous component expressing alpha fetoprotein. The rapid growth of the tumour prevented any attempt at treatment. Although direct evidence is lacking, the most likely hypothesis to explain the observations is a marked phenotypic change in the initial malignant population at recurrence. CONCLUSION: This case supports a possible filiation between hepatocellular carcinoma and hepatoblastoma in adults.
J Dumortier; T Bizollon; M Chevallier; C Ducerf; J Baulieux; J Y Scoazec; C Trepo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gut     Volume:  45     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-01     Completed Date:  1999-11-01     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  622-5     Citation Subset:  AIM; IM    
Unité d'Hépatologie, Hôtel-Dieu, Lyon, France.
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MeSH Terms
Carcinoma, Hepatocellular / surgery*
Hepatoblastoma / pathology*
Liver Neoplasms / pathology*,  surgery
Liver Transplantation*
Middle Aged
Neoplasm Recurrence, Local / pathology*

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