Document Detail

Recurrence of hepatitis-associated aplastic anemia after a 10-year interval.
MedLine Citation:
PMID:  18827426     Owner:  NLM     Status:  MEDLINE    
Hepatitis-associated aplastic anemia (HAA) has been reported to show a successful outcome following immunosuppressive treatment. On the other hand, the long-term prognosis of HAA has not been sufficiently clarified. Herein we report a patient with HAA who had been treated with cyclosporine for one year, and maintained complete remission without treatment. Ten years later, acute non-A, non-B, and non-C hepatitis reccurred followed by bone marrow aplasia. A second immunosuppressive treatment with antithymocyte globulin and cyclosporine was effective. This case might provide useful information for the long-term follow-up of patients with HAA.
Tsuyoshi Muta; Yoshinori Tanaka; Eiji Takeshita; Yuichi Kobayashi; Takahito Tokuyama; Yoko Ueda; Koji Joko; Tomoaki Fujisaki; Eisuke Yokota
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-10-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  47     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-01     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1733-7     Citation Subset:  IM    
Department of Hematology, Matsuyama Red Cross Hospital.
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MeSH Terms
Anemia, Aplastic / complications*,  drug therapy,  pathology
Antilymphocyte Serum / therapeutic use
Cyclosporine / therapeutic use
Hepatitis / drug therapy,  etiology*,  pathology
Immunosuppressive Agents / therapeutic use
Methylprednisolone / therapeutic use
Time Factors
Reg. No./Substance:
0/Antilymphocyte Serum; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine; 83-43-2/Methylprednisolone

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