Document Detail

Recurrence of dense deposits in transplanted kidney: II. Serum complement and nephritic factor profiles.
MedLine Citation:
PMID:  390216     Owner:  NLM     Status:  MEDLINE    
Dense deposit disease of the kidney is a rare form of chronic glomerulonephritis frequently associated with serum complement abnormalities (low C3 levels) and a circulating C3 convertase activator of the alternative pathway, the C3 nephritic factor (NF). Eleven patients with end-stage dense deposit disease underwent kidney transplantation. Of the 11, 7 had pretransplant low C3 and NF. In the posttransplant period, persisting low C3 levels were associated with persisting NF, although not quantitatively so. The original glomerular lesion recurred in the graft within 6 months in 9 of 11. Of these 9, 2 had no complement abnormalities either prior to or after transplantation. Pretransplant complement abnormalities were rapidly corrected in 4 of 7 patients whether or not recurrence of the original lesion occurred. Thus, serum complement profiles before and after transplantation are neither predictive nor indicative of recurrence.
J Leibowitch; L Halbwachs; S Wattel; M H Gaillard; D Droz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  15     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  396-403     Citation Subset:  IM    
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MeSH Terms
Complement C3 / immunology*
Complement C3 Nephritic Factor / immunology*
Complement Factor B / immunology
Complement Inactivator Proteins / immunology*
Complement Pathway, Alternative
Complement System Proteins / immunology*
Glomerulonephritis / immunology,  surgery
Kidney / immunology
Kidney Diseases / immunology,  surgery*
Kidney Transplantation*
Time Factors
Transplantation, Homologous
Reg. No./Substance:
0/Complement C3; 0/Complement C3 Nephritic Factor; 0/Complement Inactivator Proteins; 9007-36-7/Complement System Proteins; EC Factor B

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