Document Detail


Recurrence of dense deposits in transplanted kidney: II. Serum complement and nephritic factor profiles.
MedLine Citation:
PMID:  390216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dense deposit disease of the kidney is a rare form of chronic glomerulonephritis frequently associated with serum complement abnormalities (low C3 levels) and a circulating C3 convertase activator of the alternative pathway, the C3 nephritic factor (NF). Eleven patients with end-stage dense deposit disease underwent kidney transplantation. Of the 11, 7 had pretransplant low C3 and NF. In the posttransplant period, persisting low C3 levels were associated with persisting NF, although not quantitatively so. The original glomerular lesion recurred in the graft within 6 months in 9 of 11. Of these 9, 2 had no complement abnormalities either prior to or after transplantation. Pretransplant complement abnormalities were rapidly corrected in 4 of 7 patients whether or not recurrence of the original lesion occurred. Thus, serum complement profiles before and after transplantation are neither predictive nor indicative of recurrence.
Authors:
J Leibowitch; L Halbwachs; S Wattel; M H Gaillard; D Droz
Related Documents :
18209336 - The spectrum of glomerulonephritis in saudi arabia: the results of the saudi registry.
860726 - Partial lipodystrophy, c3 nephritic factor and clinically inapparent mesangiocapillary ...
9279256 - Bronchiolitis obliterans and iga nephropathy. a new cause of pulmonary-renal syndrome.
10805466 - Expression of ki-67 antigen using monoclonal antibody mib-1 in children with post-strep...
9347816 - Elemental mercurial poisoning.
23958926 - No acceleration of uv-induced skin carcinogenesis from evenly spread dietary intake of ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  15     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1980-02-26     Completed Date:  1980-02-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  396-403     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Complement C3 / immunology*
Complement C3 Nephritic Factor / immunology*
Complement Factor B / immunology
Complement Inactivator Proteins / immunology*
Complement Pathway, Alternative
Complement System Proteins / immunology*
Glomerulonephritis / immunology,  surgery
Humans
Kidney / immunology
Kidney Diseases / immunology,  surgery*
Kidney Transplantation*
Recurrence
Time Factors
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Complement C3; 0/Complement C3 Nephritic Factor; 0/Complement Inactivator Proteins; 9007-36-7/Complement System Proteins; EC 3.4.21.47/Complement Factor B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recurrence of dense deposits in transplanted kidneys: I. Sequential survey of the lesions.
Next Document:  Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capil...