| Recurrence of dense deposits in transplanted kidney: II. Serum complement and nephritic factor profiles. | |
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MedLine Citation:
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PMID: 390216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dense deposit disease of the kidney is a rare form of chronic glomerulonephritis frequently associated with serum complement abnormalities (low C3 levels) and a circulating C3 convertase activator of the alternative pathway, the C3 nephritic factor (NF). Eleven patients with end-stage dense deposit disease underwent kidney transplantation. Of the 11, 7 had pretransplant low C3 and NF. In the posttransplant period, persisting low C3 levels were associated with persisting NF, although not quantitatively so. The original glomerular lesion recurred in the graft within 6 months in 9 of 11. Of these 9, 2 had no complement abnormalities either prior to or after transplantation. Pretransplant complement abnormalities were rapidly corrected in 4 of 7 patients whether or not recurrence of the original lesion occurred. Thus, serum complement profiles before and after transplantation are neither predictive nor indicative of recurrence. |
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Authors:
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J Leibowitch; L Halbwachs; S Wattel; M H Gaillard; D Droz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kidney international Volume: 15 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1979 Apr |
Date Detail:
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Created Date: 1980-02-26 Completed Date: 1980-02-26 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 396-403 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Complement C3
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immunology* Complement C3 Nephritic Factor / immunology* Complement Factor B / immunology Complement Inactivator Proteins / immunology* Complement Pathway, Alternative Complement System Proteins / immunology* Glomerulonephritis / immunology, surgery Humans Kidney / immunology Kidney Diseases / immunology, surgery* Kidney Transplantation* Recurrence Time Factors Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C3 Nephritic Factor; 0/Complement Inactivator Proteins; 9007-36-7/Complement System Proteins; EC 3.4.21.47/Complement Factor B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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