| Rectogesic (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures. | |
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MedLine Citation:
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PMID: 17504344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Some haemorrhoids are associated with high resting anal canal pressures. The aim of this study was to assess if Rectogesic, a topical glyceryl trinitrate 0.2% ointment was effective in relieving symptoms of early grade haemorrhoids associated with high resting anal canal pressures. METHOD: This was a prospective, two-centre, open label study of 58 patients with persistent haemorrhoidal symptoms. Patients with first or second degree haemorrhoids and a maximum resting anal canal pressure > 70 mmHg were included. Rectogesic was applied three times a day for 14 days. Anorectal manometry was performed 30 min after the first application of Rectogesic. A 28-day diary was completed during 14 days of therapy and for 14 days after cessation of treatment. This recorded the incidence of rectal bleeding, and visual analogue scales for anal pain, throbbing, pruritus, irritation and difficulty in bowel movement. RESULTS: Maximum resting anal canal pressures were reduced after application of Rectogesic (115.0 +/- 40.4 mmHg vs 94.7 +/- 34.1 mmHg, P < 0.001). In the study period and at 14 days after cessation of Rectogesic, there was significant reduction in rectal bleeding (P = 0.0002), and significant improvement of anal pain (P = 0.0024), throbbing (P = 0.0355), pruritus (P = 0.0043), irritation (P = 0.0000) and difficulty in bowel movement (P = 0.001). The main adverse event was headache in 43.1% of patients. CONCLUSION: Rectogesic is a safe and feasible treatment for patients with early grade haemorrhoids associated with high resting anal canal pressures. |
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Authors:
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J J Tjandra; J J Y Tan; J F Lim; C Murray-Green; M L Kennedy; D Z Lubowski |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland Volume: 9 ISSN: 1462-8910 ISO Abbreviation: Colorectal Dis Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-16 Completed Date: 2007-07-17 Revised Date: 2009-02-26 |
Medline Journal Info:
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Nlm Unique ID: 100883611 Medline TA: Colorectal Dis Country: England |
Other Details:
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Languages: eng Pagination: 457-63 Citation Subset: IM |
Affiliation:
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Department of Colorectal Surgery, Epworth Colorectal Center and The Royal Melbourne Hospital, Melbourne, Australia. tjandra@connexus.net.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anal Canal / drug effects, physiopathology Female Hemorrhage / drug therapy*, etiology Hemorrhoids / complications, drug therapy* Humans Male Manometry Middle Aged Nitroglycerin / therapeutic use* Ointments Prospective Studies Severity of Illness Index Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Ointments; 0/Vasodilator Agents; 55-63-0/Nitroglycerin |
| Comments/Corrections | |
Comment In:
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Colorectal Dis. 2008 Jan;10(1):96
[PMID:
17645569
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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