| Rectally administered misoprostol versus intravenous oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss. | |
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MedLine Citation:
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PMID: 20070961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the efficacy of rectally administered misoprostol with intravenous oxytocin infusion in preventing uterine atony and blood loss during cesarean delivery. METHODS: In this prospective, randomized, double-blind trial, 200 women undergoing cesarean delivery who did not have risk factors for postpartum hemorrhage were randomly allocated to receive either 800 microg of rectal misoprostol at the time of peritoneal incision or an intravenous infusion of oxytocin after delivery of the neonate. Primary outcome measures were estimated amount of intraoperative and postoperative (8 hours) blood loss and changes in hemoglobin levels 24 hours after delivery. RESULTS: A total of 96 and 94 women were analyzed in the misoprostol and oxytocin groups, respectively. Intraoperative and postoperative blood loss was significantly lower in the misoprostol group than in the oxytocin group (503 vs 592 mL, P=0.003 and 74 vs 114 mL, P=0.045, respectively). The incidence of shivering was higher in the misoprostol group (8.3% vs 1.1%, P=0.018; RR 7.83; 95% confidence interval, 0.99-61.42). CONCLUSION: Rectal misoprostol appears to be an effective alternative to intravenous oxytocin in preventing blood loss for routine use during cesarean delivery. Clinical Trials Registration: CTRI/2009/091/000075. |
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Authors:
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Picklu Chaudhuri; Gita Basu Banerjee; Apurba Mandal |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-01-13 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 109 ISSN: 1879-3479 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 25-9 Citation Subset: IM |
Copyright Information:
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Copyright 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, Chittaranjan Sevasadan College of Obstetrics, Gynecology and Child Health, Kolkata, Westbengal, India. picklu.chaudhuri@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Rectal Adult Blood Loss, Surgical / prevention & control Cesarean Section / adverse effects* Double-Blind Method Female Humans Infusions, Intravenous Misoprostol / administration & dosage* Oxytocics / administration & dosage* Oxytocin / administration & dosage* Postoperative Complications / prevention & control* Pregnancy Prospective Studies Uterine Inertia / prevention & control* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 50-56-6/Oxytocin; 59122-46-2/Misoprostol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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