| Rectal sensorimotor dysfunction in constipation. | |
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MedLine Citation:
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PMID: 21382582 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The pathophysiological mechanisms underlying chronic constipation in both adults and children remain to be unravelled. This is a not inconsiderable challenge, but is fundamental to improving management of such patients. Rectal sensorimotor function, which encompasses both sensation and motility, as well as biomechanical components (compliance, capacity), is now strongly implicated in the pathogenesis of constipation. Rectal hyposensitivity, rectal hypercompliance, increased rectal capacity, rectal motor dysfunction (phasic contractility and tone), and altered rectoanal reflex activity are all found in constipated patients, particularly in association with 'functional' disorders of defaecation (i.e. pelvic floor dyssynergia). This review covers contemporary understanding of how components of rectal sensorimotor function may contribute to symptom development in both adult and paediatric populations. The complex interaction between sensory/motor/biomechanical domains, and how best to measure these functions are addressed, and where data exist, the impact of sensorimotor dysfunction on therapeutic outcomes is highlighted. |
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Authors:
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S M Scott; M M van den Berg; M A Benninga |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Best practice & research. Clinical gastroenterology Volume: 25 ISSN: 1532-1916 ISO Abbreviation: Best Pract Res Clin Gastroenterol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120605 Medline TA: Best Pract Res Clin Gastroenterol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 103-18 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Academic Surgical Unit & Neurogastroenterology Group, Barts and The London School of Medicine and Dentistry, Queen Mary University London, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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