Document Detail

Rectal mucosal major basic protein in infants with dietary protein-induced colitis.
MedLine Citation:
PMID:  8328717     Owner:  NLM     Status:  MEDLINE    
Dietary protein-induced colitis is a frequent cause of rectal bleeding in infants. The exact pathogenic mechanism is unknown but the disorder has been thought to be due to an allergic response. Rectal mucosal edema and eosinophilia are typically found but there are no specific markers currently available. Because eosinophil degranulation, as evidenced by the release of major basic protein, has been implicated in hypersensitivity disorders, we aimed to assess major basic protein deposition as a marker of dietary protein-induced colitis occurring in young infants. Suction rectal biopsies from five infants aged 1 to 7 months with findings consistent with dietary protein-induced colitis were compared histologically with five age matched controls who underwent rectal biopsies to rule out Hirschsprung's disease. An established indirect immunofluorescent staining method was used to identify tissue major basic protein. Comparable rectal deposition of major basic protein was found for the controls and colitic patients. Mucosal eosinophilia but not mast cell content was more prominent in the colitic patients (P < .05) than in the controls. Some of the colitic infants had elevated serum IgE levels (1 of 5), positive RAST for milk (2 of 5), and peripheral blood eosinophilia (1 of 5). Our findings do not support the concept that dietary protein-induced colitis of infancy is due solely to an immediate hypersensitivity response. The results also indicate that major basic protein is probably not a marker or likely primary mediator of this disorder.
D W Thomas; N J Talley; V Mahnovski; M Haight; F R Sinatra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy     Volume:  71     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Childrens Hospital Los Angeles, California.
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MeSH Terms
Blood Proteins / analysis*
Cell Degranulation
Colitis / chemically induced*,  metabolism,  pathology
Dietary Proteins / adverse effects*
Eosinophil Granule Proteins
Eosinophils / cytology
Infant, Newborn
Intestinal Mucosa / chemistry*,  pathology
Mast Cells / cytology
Rectum / pathology
Reg. No./Substance:
0/Blood Proteins; 0/Dietary Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases

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