| Rectal lactate levels in endoluminal microdialysate during routine coronary surgery. | |
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MedLine Citation:
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PMID: 17300302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this prospective study was to determine the feasibility of intestinal endoluminal microdialysis as a new method for clinical monitoring of the adequacy of splanchnic perfusion in the large bowel. A microdialysis catheter for continuous lactate, glycerol, glucose and pyruvate measurements attached to a tonometric catheter was placed into the lumen of the recto-sigmoid junction prior to surgery in 13 patients undergoing elective cardiac surgery with cardiopulmonary bypass (CPB). Lactate was also measured in blood and muscle. CPB was associated with a 10-fold increase in luminal lactate from 0.16 (0.01) to 1.67 (0.38) mmol x l(-1) (p < 0.001). Muscular lactate increased from baseline levels 1.20 (0.21) to 1.77 (0.36) mmol x l(-1) during CPB (p = 0.01), but the muscular lactate-pyruvate ratio remained unchanged. Arterial lactate increased only slightly from 0.9 (0.05) to 1.1 (0.06) mmol x l(-1) (p = 0.027) during CPB. Increased lactate concentrations in the large bowel during CPB are suggestive of local lactate production consistent with impaired oxygen delivery. Intestinal endoluminal microdialysis is a potential clinically applicable method for monitoring intestinal metabolism. Combined with tonometry, microdialysis provides the opportunity to monitor both circulation and metabolism in the rectal mucosa. |
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Authors:
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E Solligård; A Wahba; E Skogvoll; R Stenseth; J E Grønbech; P Aadahl |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anaesthesia Volume: 62 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-15 Completed Date: 2007-04-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 250-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care, St Olav University Hospital, Norwegian University of Science and Technology, N-7006 Trondheim, Norway. erik.solligard@ntnu.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure Cardiopulmonary Bypass Coronary Artery Bypass* Feasibility Studies Humans Intestinal Mucosa / blood supply, metabolism Lactic Acid / blood, metabolism* Male Manometry / methods Microdialysis / methods* Middle Aged Monitoring, Intraoperative / methods* Oxygen Consumption Postoperative Period Prospective Studies Rectum / blood supply, metabolism* Splanchnic Circulation Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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