Document Detail


Recruitment of participants for the multiple risk factor intervention trial (MRFIT).
MedLine Citation:
PMID:  3440389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Multiple Risk Factor Intervention Trial (MRFIT) was a randomized primary prevention trial designed to test the effect of multifactor intervention on mortality from coronary heart disease. Before randomization, men were seen at three screening visits to establish eligibility. A total of 361,662 men were screened, and 12,866 men were randomized, 866 more than the goal of 12,000. The total time required for planning and recruitment was 44 months. Eligibility rates and dropout or refusal rates between screening visits varied considerably among the 20 clinics that took part in MRFIT. The variation in eligibility rates resulted largely from subjective interpretation by the staff of the willingness of the men to participate in the study and to make risk factor changes. Cigarette smokers and blacks were more likely to discontinue their participation between screening exams. The ultimate success of the MRFIT recruitment is attributed to (1) the previous experience of investigators in screening large numbers of participants for clinical trials and similar epidemiologic investigations, (2) the identification at each clinic of one or more persons whose specific responsibility was recruitment, (3) the phased entry of clinics into the study, (4) routine monitoring and reporting of recruitment rates by the coordinating center, (5) regular discussion of recruitment successes and problems at the Steering Committee meetings, and (6) site visits to examine in detail recruitment problems.
Authors:
J D Neaton; R H Grimm; J A Cutler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Controlled clinical trials     Volume:  8     ISSN:  0197-2456     ISO Abbreviation:  Control Clin Trials     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-04-21     Completed Date:  1988-04-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006242     Medline TA:  Control Clin Trials     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41S-53S     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic / methods*
Coronary Disease / prevention & control*
Humans
Male
Mass Screening / methods
Patients*
Primary Prevention
Random Allocation
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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