| Recruitment of lung diffusing capacity: update of concept and application. | |
| | |
MedLine Citation:
|
PMID: 12426283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lung diffusing capacity (DL) for carbon monoxide (DLCO), nitric oxide (DLNO) or oxygen (DLO2) increases from rest to peak exercise without reaching an upper limit; this recruitment results from interactions among alveolar volume (VA), and cardiac output (q), as well as changing physical properties and spatial distribution of capillary erythrocytes, and is critical for maintaining a normal arterial oxygen saturation. DLCO and DLNO can be used to interpret the effectiveness of diffusive oxygen transport and track structural alterations of the alveolar-capillary barrier, providing sensitive noninvasive indicators of microvascular integrity in health and disease. Clinical interpretation of DL should take into account Q in addition to VA and hemoglobin concentration. |
| | |
Authors:
|
Connie C W Hsia |
Related Documents
:
|
3519893 - Exercise increases the lung clearance of inhaled technetium-99m dtpa. 2707403 - A simultaneous single breath measurement of pulmonary diffusing capacity with nitric ox... 19910943 - Impact of 6-month caloric restriction on autonomic nervous system activity in healthy, ... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Chest Volume: 122 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2002 Nov |
Date Detail:
|
Created Date: 2002-11-11 Completed Date: 2002-12-30 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
|
Languages: eng Pagination: 1774-83 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas TX 75390-9034, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Erythrocytes Exercise Heart Diseases / physiopathology Hematocrit Humans Lung Diseases / physiopathology Pulmonary Alveoli Pulmonary Diffusing Capacity* / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
HL62873/HL/NHLBI NIH HHS; R01-HL45716/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Real-time chest ultrasonography: a comprehensive review for the pulmonologist.
Next Document: Adrenal insufficiency in the critically ill: a new look at an old problem.