Document Detail


Recruitment of lung diffusing capacity: update of concept and application.
MedLine Citation:
PMID:  12426283     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lung diffusing capacity (DL) for carbon monoxide (DLCO), nitric oxide (DLNO) or oxygen (DLO2) increases from rest to peak exercise without reaching an upper limit; this recruitment results from interactions among alveolar volume (VA), and cardiac output (q), as well as changing physical properties and spatial distribution of capillary erythrocytes, and is critical for maintaining a normal arterial oxygen saturation. DLCO and DLNO can be used to interpret the effectiveness of diffusive oxygen transport and track structural alterations of the alveolar-capillary barrier, providing sensitive noninvasive indicators of microvascular integrity in health and disease. Clinical interpretation of DL should take into account Q in addition to VA and hemoglobin concentration.
Authors:
Connie C W Hsia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Chest     Volume:  122     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-11     Completed Date:  2002-12-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1774-83     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas TX 75390-9034, USA.
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MeSH Terms
Descriptor/Qualifier:
Erythrocytes
Exercise
Heart Diseases / physiopathology
Hematocrit
Humans
Lung Diseases / physiopathology
Pulmonary Alveoli
Pulmonary Diffusing Capacity* / physiology
Grant Support
ID/Acronym/Agency:
HL62873/HL/NHLBI NIH HHS; R01-HL45716/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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