Document Detail

Recruitment of effector lymphocytes by initiator lymphocytes: role of a trypsin-sensitive membrane component.
MedLine Citation:
PMID:  1086237     Owner:  NLM     Status:  MEDLINE    
In earlier studies we found that initiator T lymphocytes sensitized in vitro against fibroblasts were able to recruit immunospecific effector T lymphocytes in vivo in syngeneic mice. In the present study, to investigate the possible function in effector cell recruitment of sensitizing antigens passively adsorbed onto the initiator cell membrane, we treated the initiator lymphocytes with trypsin. We found that trypsin inhibited recruitment. However, the initiator cells spontaneously recovered their recruiting ability after incubation in vitro for 4 h in the absence of contact with sensitizing antigens. Recovery could be blocked by cycloheximide. Hence, it appears that recruitment depends on the intrinsic metabolic function of the initiator lymphocytes and is not due merely to passively-adsorbed antigen carried over into the recipient mouse.
S Livnat; I R Cohen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of immunology     Volume:  5     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1975 May 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  357-60     Citation Subset:  IM    
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MeSH Terms
Cell Membrane / immunology
Immunity, Cellular*
Membrane Proteins / immunology*
Mice, Inbred Strains
T-Lymphocytes / immunology*
Time Factors
Reg. No./Substance:
0/Antigens; 0/Membrane Proteins; EC

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