Document Detail

Recruitment of depressive patients for a controlled clinical trial in a psychiatric practice.
MedLine Citation:
PMID:  10958263     Owner:  NLM     Status:  MEDLINE    
Attempts were made to recruit moderately depressed patients to a randomized double-blind study with a new serotonergic-noradrenergic antidepressant in a psychiatry specialist's practice. Although 216 patients consulting a psychiatrist for depression were screened, none were suitable for recruitment into the study. The most common causes of exclusion were severity of depression (n = 199, 92.1%), concomitant treatment with other psychotropic drugs (n = 124, 57.4%) and pre-treatment with an SSRI or MAO-inhibitor (n = 97, 44.9%). On average, there were 3.4 criteria per patient that resulted in exclusion from the study. The difficulties in recruiting patients demonstrate that psychopharmacological studies with the usual inclusion and exclusion criteria are hardly practicable in an office-based psychiatric practice. Furthermore, the question to what extent results from studies performed under restrictive inclusion and exclusion criteria are applicable to routine care must also be put.
E M Haberfellner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  33     ISSN:  0176-3679     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-14     Completed Date:  2000-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  142-4     Citation Subset:  IM    
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MeSH Terms
Antidepressive Agents / therapeutic use*
Depressive Disorder / drug therapy*,  psychology*
Double-Blind Method
Patient Selection*
Randomized Controlled Trials as Topic / methods*
Research Design
Reg. No./Substance:
0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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