| Recruitment of depressive patients for a controlled clinical trial in a psychiatric practice. | |
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MedLine Citation:
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PMID: 10958263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Attempts were made to recruit moderately depressed patients to a randomized double-blind study with a new serotonergic-noradrenergic antidepressant in a psychiatry specialist's practice. Although 216 patients consulting a psychiatrist for depression were screened, none were suitable for recruitment into the study. The most common causes of exclusion were severity of depression (n = 199, 92.1%), concomitant treatment with other psychotropic drugs (n = 124, 57.4%) and pre-treatment with an SSRI or MAO-inhibitor (n = 97, 44.9%). On average, there were 3.4 criteria per patient that resulted in exclusion from the study. The difficulties in recruiting patients demonstrate that psychopharmacological studies with the usual inclusion and exclusion criteria are hardly practicable in an office-based psychiatric practice. Furthermore, the question to what extent results from studies performed under restrictive inclusion and exclusion criteria are applicable to routine care must also be put. |
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Authors:
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E M Haberfellner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacopsychiatry Volume: 33 ISSN: 0176-3679 ISO Abbreviation: Pharmacopsychiatry Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-12-14 Completed Date: 2000-12-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8402938 Medline TA: Pharmacopsychiatry Country: GERMANY |
Other Details:
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Languages: eng Pagination: 142-4 Citation Subset: IM |
Affiliation:
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e.m.haberfellner@aon.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents / therapeutic use* Depressive Disorder / drug therapy*, psychology* Double-Blind Method Humans Patient Selection* Randomized Controlled Trials as Topic / methods* Research Design |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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