Document Detail


Recruitment of CD34+ progenitor cells into peripheral blood and asthma severity.
MedLine Citation:
PMID:  18939729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies have suggested that the number of progenitor cells is elevated in the peripheral blood of asthmatic patients and that the number of progenitors correlate with the severity of the disease. OBJECTIVE: To evaluate the number of leukocyte progenitor and eosinophil progenitor cells in the peripheral blood of patients with bronchial asthma in relation to disease severity. METHODS: The study involved 51 patients with asthma (25 patients with a mild form and 26 with a severe form of the disease) and a group of 12 healthy controls. Using the flow cytometric method, leukocyte (CD34+ leukocytes) and eosinophil progenitors (CD34+CD125+) were detected in the peripheral blood of both asthmatic patients and healthy controls. RESULTS: Patients with asthma had significantly more leukocyte progenitor cells (median, 0.06% vs 0.016%) and eosinophil progenitor cells (median, 0.046% vs 0.004%) compared with the controls. Patients with severe asthma had more leukocyte progenitor cells (0.12% vs 0.035%) and more eosinophil progenitor cells (0.102% vs 0.019%) than patients with mild asthma. The number of circulating leukocyte and eosinophil progenitor cells inversely correlated with the forced expiratory volume in 1 second percentage of predicted value (r = -0.4 and r = -0.35, respectively) and positively correlated (r = 0.63 and r = 0.65, respectively) with the dose of inhaled steroids used to control asthma. CONCLUSION: These data suggest that the presence of leukocyte precursors and eosinophil progenitor cells in the peripheral blood of asthmatic patients may reflect ongoing airway inflammation.
Authors:
Joanna S Makowska; Janina Grzegorczyk; Malgorzata Ciéslak; Barbara Biénkiewicz; Marek L Kowalski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  101     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-6     Citation Subset:  IM    
Affiliation:
Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD34 / analysis*
Asthma / blood*,  immunology
B-Lymphocytes / cytology
Eosinophils / cytology,  immunology
Female
Granulocyte Precursor Cells* / immunology
Hematopoietic Stem Cells* / immunology
Humans
Leukocyte Count
Leukocytes / cytology*
Lymphoid Progenitor Cells* / immunology
Male
Middle Aged
T-Lymphocytes / cytology
Chemical
Reg. No./Substance:
0/Antigens, CD34

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