Document Detail


Recruitment of African American and white postmenopausal women into clinical trials: the beneficial effects of soy trial experience.
MedLine Citation:
PMID:  17061750     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe the strategies and costs associated with recruiting both African American and White postmenopausal women into a randomized controlled trial.
DESIGN: The Beneficial Effects of Soy Trial (BEST) was a randomized, controlled trial designed to determine the effects of a dietary soy supplement on lipoproteins, lipoprotein subclasses, and menopausal symptoms in African American and White postmenopausal women. The goal was to have > or = 80 African American and > or = 80 White women complete the study.
RESULTS: A total of 705 postmenopausal women (381 African American, 324 White) were screened, and of those, 217 were randomized (105 African American, 112 White), and 192 (91 African American, 101 White) completed the study. Direct mailings to targeted zip codes proved the most successful recruitment strategy for recruiting African Americans (52% of African Americans recruited) and the second most effective for recruiting Whites (32% of Whites recruited). Newspaper advertisements yielded the highest number of White participants (36%) but proved less successful for recruiting African Americans (8%). Airing advertisements on the radio was the second most effective strategy for recruiting African Americans (15%), yet it was one of the least effective approaches for recruiting Whites (5%). The total cost of recruitment was dollar 49,036.25, which averaged dollar 255.40 per participant who completed the study. The three most successful strategies, direct mailings, newspaper ads, and radio ads, were the three most expensive approaches but yielded 73% of all participants who completed the study.
Authors:
Kathleen A Lindenstruth; Carol B Curtis; Jerilyn K Allen
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Ethnicity & disease     Volume:  16     ISSN:  1049-510X     ISO Abbreviation:  Ethn Dis     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-25     Completed Date:  2007-07-11     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  9109034     Medline TA:  Ethn Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  938-42     Citation Subset:  IM    
Affiliation:
Johns Hopkins University, School of Nursing, Baltimore, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
African Americans*
Aged
Baltimore / ethnology
Biological Markers / blood
Cholesterol, LDL / blood,  drug effects
Cost-Benefit Analysis
Dietary Supplements / economics
Double-Blind Method
European Continental Ancestry Group*
Female
Follow-Up Studies
Humans
Investments / statistics & numerical data
Middle Aged
Minority Groups
Patient Selection*
Postmenopause / blood,  ethnology*
Soybean Proteins / administration & dosage*,  economics
Treatment Outcome
Triglycerides / blood
Grant Support
ID/Acronym/Agency:
1R01 HL70553-01/HL/NHLBI NIH HHS; R01 HL070553/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, LDL; 0/Soybean Proteins; 0/Triglycerides
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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