| Recovery of vision after adjuvant thalidomide in a child with tuberculous meningitis and acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 19182153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 7-year-old child, on maintenance chemotherapy for acute lymphoblastic leukemia, developed tuberculous meningitis complicated by progressive basal meningeal inflammation and abscess formation, in spite of adequate tuberculosis treatment and adjunctive corticosteriod therapy. The child became blind as a result of involvement of the optic chiasm. After 2 months of adjunctive thalidomide therapy, the child regained vision and cranial magnetic resonance imaging showed marked reduction of the inflammatory changes previously demonstrated. Progression of intracranial tuberculous infection, in spite of a treatment that is generally considered to be adequate, is well recognized. Previous reports of a possible beneficiary role of thalidomide in these cases support an immunological basis. The present case suggests a role for thalidomide in the treatment of blindness due to involvement of the optic chiasm in progressive basal tuberculous meningitis. |
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Authors:
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Daniela Cristina Stefan; Savvas Andronikou; Nicola Freeman; Johan Schoeman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 24 ISSN: 1708-8283 ISO Abbreviation: J. Child Neurol. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-02 Completed Date: 2009-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 166-9 Citation Subset: IM |
Affiliation:
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Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg Children's Hospital, Cape Town, South Africa. cs@sun.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use Blindness / drug therapy*, etiology Brain / drug effects, pathology Chemotherapy, Adjuvant Child Humans Immunosuppressive Agents / therapeutic use Magnetic Resonance Imaging Male Optic Chiasm / drug effects, physiopathology Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*, drug therapy, physiopathology Recovery of Function / drug effects Thalidomide / therapeutic use* Tuberculosis, Meningeal / complications*, pathology, physiopathology Vision, Ocular / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents; 50-35-1/Thalidomide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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