Document Detail

Recovery of ureteric motility following complete and partial ureteric obstruction.
MedLine Citation:
PMID:  8281398     Owner:  NLM     Status:  MEDLINE    
Complete and partial ureteric obstruction was created in 2 groups of 10 mongrel dogs by placing a ligature around, or inserting a fine bore plastic stent into, the lower end of the left ureter (Groups 1 and 2). After 4 weeks the ligature or stent was removed, a 2.5-cm segment of ureter was harvested for in vitro analysis and the ureter reimplanted into the bladder. Pelvic and ureteric pressures and motility were recorded before, during and after the period of obstruction via a subcutaneously placed nephrostomy tube. Pre-obstruction resting intra-ureteric pressure was 2.1 +/- 0.3 mm Hg (mean +/- SEM), with regular contractions 8.9 +/- 0.7/min of 36.2 +/- 1.2 mm Hg amplitude. After 4 weeks of obstruction, contractility was abolished in Group 1 but increased in Group 2, 71.5 +/- 3.3 mm Hg, with irregular multiphasic contractions seen following diuresis. Intra-ureteric pressure was 16.3 + 1.2 mm Hg in Group 1 and 9.3 + 1.2 mm Hg in Group 2. In vitro experiments confirmed the patterns of contractility seen in vivo. Eight weeks after reimplantation the ureter returned to normal rhythm and rate in Group 1, but increased contractility persisted both in vivo and in vitro in Group 2.
G M Lennon; P C Ryan; J M Fitzpatrick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of urology     Volume:  72     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-14     Completed Date:  1994-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  702-7     Citation Subset:  IM    
Department of Urology/Surgery, Mater Misericordiae Hospital, Dublin, Ireland.
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MeSH Terms
Disease Models, Animal
Kidney Pelvis / physiopathology
Ureter / physiopathology*
Ureteral Obstruction / physiopathology*

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