| Recovery and recurrence of left ventricular systolic dysfunction in patients with idiopathic dilated cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 19417864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Some patients with nonischemic left ventricular (LV) systolic failure recover to have normal LV systolic function. However, few studies on the rates of recovery and recurrence have been reported, and no definitive indicators that can predict the recurrence of LV dysfunction in recovered idiopathic dilated cardiomyopathy (IDCMP) patients have been determined. It was hypothesized that patients who recovered from nonischemic LV dysfunction have a substantial risk for recurrent heart failure. METHODS: Forty-two patients (32 men) with IDCMP (mean [+/- SD] age 56.9+/-8.7 years) who recovered from systolic heart failure (LV ejection fraction [LVEF] of 26.5+/-6.9% at initial presentation) to a near-normal state (LVEF of 40% or greater, and a 10% increase or greater in absolute value) were monitored for recurrence of LV systolic dysfunction. Patients with significant coronary artery disease were excluded. Patients were monitored for 41.0+/-26.3 months after recovery (LVEF 53.4+/-7.6%) from LV dysfunction. RESULTS: LV systolic dysfunction reappeared (LVEF 27.5+/-8.1%) during the follow-up period in eight of 42 patients (19.0%). No significant difference between the groups with or without recurrent heart failure was observed in the baseline clinical and echocardiographic characteristics. However, more patients in the recurred IDCMP group than those in the group that maintained the recovery state had discontinued antiheart failure medication (62.5% versus 5.9%, P<0.05). CONCLUSIONS: LV dysfunction recurs in some patients with reversible IDCMP. The recurrence was significantly correlated with the discontinuation of antiheart failure drugs. The results suggest that continuous medical therapy may be mandatory in patients who recover from LV systolic dysfunction. |
| | |
Authors:
|
Jeonggeun Moon; Young-Guk Ko; Namsik Chung; Jong-Won Ha; Seok-Min Kang; Eui-Young Choi; Se-Joong Rim |
Related Documents
:
|
18002074 - Analysis of left ventricular surface deformation during isovolumic contraction. 15731374 - Assessment of regional left ventricular function: accuracy and reproducibility of posit... 16357484 - Transient left ventricular apical ballooning. report of 5 israeli patients. 20923324 - Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with ri... 15972864 - Sudden death in patients with myocardial infarction and left ventricular dysfunction, h... 521294 - A model of prehospital death from ventricular fibrillation following myocardial infarct... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Canadian journal of cardiology Volume: 25 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-05-06 Completed Date: 2009-06-11 Revised Date: 2013-06-02 |
Medline Journal Info:
|
Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
|
Languages: eng Pagination: e147-50 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cardiac Catheterization / methods Cardiomyopathy, Dilated / diagnosis*, drug therapy, mortality Cardiotonic Agents / therapeutic use Cohort Studies Echocardiography, Doppler Electrocardiography Female Heart Failure, Systolic / diagnosis*, drug therapy, mortality Heart Function Tests Humans Kaplan-Meier Estimate Logistic Models Male Middle Aged Monitoring, Physiologic / methods Probability Prognosis Recurrence Retrospective Studies Risk Assessment Severity of Illness Index Survival Analysis Ventricular Dysfunction, Left / diagnosis*, drug therapy, mortality Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Resistant hypertension.
Next Document: Sex differences in resource use after on-pump and off-pump coronary artery bypass surgery: a propens...