| Recovery of rat growth and lipid profiles in adult rats subjected to fetal protein malnutrition with a fructose-rich diet. | |
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MedLine Citation:
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PMID: 20227002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is evidence suggesting an association between fructose consumption and the development of metabolic syndrome. In turn, protein malnutrition in utero is proposed to "program" the fetal tissues, making them more susceptible to nutritional associated disorders. To test this hypothesis, the present study was designed to analyze body growth and metabolic aspects of rats subjected to fetal protein malnutrition and subsequently fed a fructose-rich diet. Wistar rats were distributed into 4 groups: balanced (B) diet-B diet offered the entire experimental period; balanced diet/fructose-B diet until birth and fructose-rich diet (F-60% fructose) until adulthood; low-protein (L) diet/balanced-L diet until birth and B diet until adulthood; low-protein diet/fructose (F)-L diet until birth and F diet until adulthood. After nutritional recovery, there was a restoration of serum glucose, total protein, and albumin concentrations, which were reduced by fetal malnutrition, and a restoration of the liver glycogen and lipids contents, which were increased by fetal malnutrition. This restoration was independent of the diet adopted after birth. It was verified that the high fructose diet arrested body growth of the rats independently of the nutritional state during fetal life and was associated with weight reduction and decrease of the adipose in some regions of the body (P < .05). Moreover, the serum concentrations of triglycerides and total cholesterol, which are indicators of metabolic syndrome, rose in the rats that ingested the fructose-rich diet (P < .05). In summary, high consumption of fructose impairs body growth and alters the circulating lipids independently of the protein nutrition in utero. |
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Authors:
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Lucieli T Cambri; Ana C Ghezzi; Carla Ribeiro; Rodrigo A Dalia; Maria A Rostom de Mello |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 30 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 156-62 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Physical Education, São Paulo State University (UNESP), Rio Claro-SP, Brazil. lucambri@yahoo.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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metabolism Animals Blood Glucose Diet, Protein-Restricted Dietary Sucrose / administration & dosage* Female Fetal Development / drug effects Fetal Nutrition Disorders / diet therapy, physiopathology* Fructose / pharmacology* Growth / drug effects* Lipid Metabolism* Liver Glycogen / metabolism Male Pregnancy Prenatal Exposure Delayed Effects Protein-Energy Malnutrition / diet therapy, physiopathology* Proteins / metabolism Rats Rats, Wistar Weight Gain / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Blood Glucose; 0/Dietary Sucrose; 0/Liver Glycogen; 0/Proteins; 30237-26-4/Fructose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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