Document Detail


Recovery of left ventricular function after myocardial infarction can be predicted immediately after thrombolysis by semiquantitative intracoronary thallium and technetium pyrophosphate scintigraphy.
MedLine Citation:
PMID:  2850185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The accuracy with which intracoronary thallium and technetium pyrophosphate scintigraphy during intracoronary thrombolysis predicts myocardial salvage was studied in 58 patients with acute myocardial infarction by comparing the acute scintigraphic findings with subsequent left ventricular function. Scintigrams obtained before and immediately after thrombolysis were interpreted by three independent observers using a scoring system. Regional wall motion in the infarct area was determined from left ventricular (LV) cine angiograms using the center-line method. Patients with mild hypokinesis (hypokinesis less than or equal to -2 SD from normal) could be distinguished from those with severe hypokinesis (hypokinesis greater than -2 SD) using the prethrombolysis thallium score with an accuracy of 83%. Accuracy using the post-thrombolysis score was 76%. When the post-thrombolysis thallium and technetium pyrophosphate scores were combined, differentiation was possible in 91% of all patients studied, and in 100% of patients with anterior myocardial infarction. Thus, analysis of combined thallium and technetium pyrophosphate scintigraphy accurately predicts recovery of LV function after thrombolysis and may be helpful in deciding whether acute percutaneous transluminal coronary angioplasty or bypass surgery should be performed after thrombolysis.
Authors:
J Schofer; F H Sheehan; R Spielmann; J Wiegand; R Montz; P E Reimitz; D G Mathey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  9     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-02-10     Completed Date:  1989-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1088-97     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Nuclear Medicine and Biostatistics University Hospital, Eppendorf, Hamburg, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Cardiac Output / drug effects
Coronary Thrombosis / drug therapy
Coronary Vessels / drug effects
Diphosphates / diagnostic use*
Female
Heart Ventricles / radionuclide imaging*
Humans
Male
Middle Aged
Myocardial Contraction / drug effects*
Myocardial Infarction / drug therapy*,  radionuclide imaging
Signal Processing, Computer-Assisted
Streptokinase / administration & dosage*
Technetium / diagnostic use*
Technetium Tc 99m Pyrophosphate
Thallium Radioisotopes / diagnostic use*
Chemical
Reg. No./Substance:
0/Diphosphates; 0/Technetium Tc 99m Pyrophosphate; 0/Thallium Radioisotopes; 7440-26-8/Technetium; EC 3.4.-/Streptokinase

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