| Recovery from stress is a function of age and telomere length. | |
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MedLine Citation:
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PMID: 18491040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cells are constantly exposed to a wide variety of stimuli and must be able to mount appropriate physiological responses in order to maintain proper form and function. Cells from every organism have evolved highly conserved mechanisms to cope with environmental changes, including the widely studied heat shock response (HSR), which is induced by a variety of cellular stresses such as heavy metal ion exposure. It has long been known that as organisms and individual cells age, their ability to appropriately cope with environmental stress is attenuated. Here, we examine the ability of two heavy metal ions (ZnCl(2), SnCl(2)) to induce the HSR in human fibroblasts by assessing the expression of heat shock proteins (Hsp90, Hsp70, and p23) and the ability of the cells to recover over time. We demonstrate that the induction and recovery of chaperone levels is attenuated with age and that cells immortalized with the human telomerase reverse transcriptase component of the telomerase enzyme do not attenuate their HSR as their replicative age increases. Our data suggest that the recovery of normal human cells from an HSR is related in part to age and the cell's overall telomere length. |
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Authors:
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Graham M Strub; Amy Depcrynski; Lynne W Elmore; Shawn E Holt |
Publication Detail:
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Type: Journal Article Date: 2008-05-20 |
Journal Detail:
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Title: Cell stress & chaperones Volume: 13 ISSN: 1355-8145 ISO Abbreviation: Cell Stress Chaperones Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-02-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9610925 Medline TA: Cell Stress Chaperones Country: Netherlands |
Other Details:
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Languages: eng Pagination: 475-82 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Medical College of Virginia Campus at Virginia Commonwealth University, Richmond, VA 23298-0662, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Aging*
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drug effects Cells, Cultured Fibroblasts / cytology, drug effects, enzymology Humans Metals, Heavy / toxicity Molecular Chaperones / metabolism Stress, Physiological* / drug effects Telomerase / metabolism Telomere / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Metals, Heavy; 0/Molecular Chaperones; EC 2.7.7.49/Telomerase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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