| Recovery from severe arsenic-induced peripheral neuropathy with 2,3-dimercapto-1-propanesulphonic acid. | |
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MedLine Citation:
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PMID: 11192465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Case Report: A 33-year-old female with a 1.5-year history of multisystem illness was diagnosed with arsenic poisoning. Twenty-four-hour urine arsenic was 1030 microg/dL (normal 0-99) and root hair arsenic was 130 microg/g (normal 0-3). Despite treatment with succimer meso-2,3-dimercaptosuccinic acid, her neuropathy progressed to ventilator dependence and quadriplegia. Subsequent intravenous treatment with 2,3-dimercapto-1-propanesulfonic acid sodium salt was associated with arsenic diuresis, marked neuropathic improvement, and extubation. At 1-year follow-up, neuropathy was limited to mild distal lower extremity weakness and sensory loss. The use of 2,3-dimercapto-1-propanesulphonic acid in the treatment of severe arsenic neuropathy was associated with increased urinary elimination of arsenic and dramatic clinical recovery. |
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Authors:
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P M Wax; C A Thornton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of toxicology. Clinical toxicology Volume: 38 ISSN: 0731-3810 ISO Abbreviation: J. Toxicol. Clin. Toxicol. Publication Date: 2000 |
Date Detail:
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Created Date: 2001-01-15 Completed Date: 2001-02-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8213460 Medline TA: J Toxicol Clin Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 777-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Emergency Medicine, University of Rochester School of Medicine, New York 14642, USA. paul_wax@urmc.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arsenic / urine Arsenic Poisoning / drug therapy* Chelating Agents / chemistry, therapeutic use* Female Humans Peripheral Nervous System Diseases / chemically induced*, drug therapy* Unithiol / chemistry, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 4076-02-2/Unithiol; 7440-38-2/Arsenic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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