| Recovery from ocular ischemic syndrome after treatment with verapamil. | |
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MedLine Citation:
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PMID: 8748556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasospasm has been implicated as a cause of amaurosis fugax, which can be controlled by administration of the calcium channel blockers nifedipine or verapamil. However, vasospasm has not previously been thought to be involved in chronic ocular ischemia. We report a patient with ocular ischemic syndrome, which may have had vasospasm as a contributing cause, since the patient also developed amaurosis fugax despite daily aspirin therapy. An 80-year-old man with chronic open-angle glaucoma developed chronic ocular ischemia characterized by progressively decreased visual acuity, pain, rubeosis, and hypotony, as well as transient visual dimming. Medical evaluation revealed no evidence of carotid stenosis, thromboembolism, or vasculitis as the cause of ocular ischemia. When the calcium channel blocker verapamil was administered, the episodes of transient visual dimming ceased immediately. In addition, soon thereafter, visual acuity improved, the rubeosis partially regressed, and the hypotony reversed. This case indicates that the calcium channel blocker verapamil may be effective in treating cases of ocular ischemic syndrome, when vasospasm is a contributing cause. |
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Authors:
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J M Winterkorn; R L Beckman |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society Volume: 15 ISSN: 1070-8022 ISO Abbreviation: J Neuroophthalmol Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-09-25 Completed Date: 1996-09-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9431308 Medline TA: J Neuroophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 209-11 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Cornell University Medical Center, New York, New York 11030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blindness / drug therapy, etiology, physiopathology Calcium Channel Blockers / therapeutic use* Chronic Disease Eye / blood supply* Glaucoma, Open-Angle / complications Humans Ischemia / drug therapy*, etiology, physiopathology Male Vasoconstriction / drug effects Verapamil / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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