Document Detail

Recovery from milk allergy in early childhood: antibody studies.
MedLine Citation:
PMID:  2715889     Owner:  NLM     Status:  MEDLINE    
We assessed the relationships of clinical symptoms and serum antibody levels during follow-up of 47 patients, aged 3 to 66 months, who were shown by formal milk challenge to have cow milk allergy. Three groups of patients were identified. Group 1 patients (n = 15) were sensitized to IgE and responded rapidly to small volumes of milk with urticaria, an exacerbation of eczema, wheeze, or vomiting. In the second group (n = 24), symptoms of milk enteropathy (vomiting and diarrhea) developed between 1 and 20 hours after milk ingestion. In the group 3 patients (n = 8), coughing, diarrhea, eczematoid rashes, or a combination of these developed more than 20 hours after normal volumes of milk were given. Serum levels of IgG, IgA, IgM, and IgE and of milk-specific anti-cow milk antibodies of these isotypes were measured initially and then at a median follow-up time of 16 months (range 6 to 39 months). In this investigation, changes in these immunologic measures during the study period were related to whether or not clinical tolerance to cow milk was achieved. At follow-up, six patients from group 1, ten from group 2, and two from group 3 were milk tolerant. No consistent change in any of the immunologic measurements was associated with remission of the disease. These findings raise the question of whether acquisition of clinical tolerance to cow milk in cow milk allergy can be attributed solely to immunologic events.
D J Hill; M A Firer; G Ball; C S Hosking
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  114     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-12     Completed Date:  1989-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  761-6     Citation Subset:  AIM; IM    
Allergy-Clinical Immunology Unit, Royal Children's Hospital, Parkville, Victoria, Australia.
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MeSH Terms
Child, Preschool
Food Hypersensitivity / classification,  etiology,  immunology*
Hypersensitivity, Delayed / immunology
Hypersensitivity, Immediate / immunology
Immunoglobulins / analysis*
Milk / adverse effects*,  immunology
Reg. No./Substance:

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