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Recovery from central nervous system changes following volatile substance misuse.
MedLine Citation:
PMID:  21609150     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This review examines cognitive, neurological, and neuroanatomical recovery associated with abstinence from volatile substance misuse (VSM). Articles describing functional or structural brain changes longitudinally or cross-sectional reports comparing current and abstinent users were identified and reviewed. A significant lack of empirical studies investigating central nervous system recovery following VSM was noted. The few case reports and group studies identified indicated that cognitive and neurological impairments appear to follow a progression of decline and progression of recovery model, with the severity of impairment related to the duration and severity of misuse, blood lead levels among leaded petrol misusers, and the duration of abstinence for recovery. By contrast, severe neurological impairment known as lead encephalopathy from sniffing leaded petrol occurred as more catastrophic or abrupt damage to cerebellar processes that may never fully recover. Neuroanatomical damage may not recover even with prolonged abstinence.
Authors:
Kylie M Dingwall; Sheree Cairney
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Substance use & misuse     Volume:  46 Suppl 1     ISSN:  1532-2491     ISO Abbreviation:  Subst Use Misuse     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602153     Medline TA:  Subst Use Misuse     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-83     Citation Subset:  IM    
Affiliation:
Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Northern Territory, Australia.
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