| Recovery from central nervous system changes following volatile substance misuse. | |
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MedLine Citation:
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PMID: 21609150 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This review examines cognitive, neurological, and neuroanatomical recovery associated with abstinence from volatile substance misuse (VSM). Articles describing functional or structural brain changes longitudinally or cross-sectional reports comparing current and abstinent users were identified and reviewed. A significant lack of empirical studies investigating central nervous system recovery following VSM was noted. The few case reports and group studies identified indicated that cognitive and neurological impairments appear to follow a progression of decline and progression of recovery model, with the severity of impairment related to the duration and severity of misuse, blood lead levels among leaded petrol misusers, and the duration of abstinence for recovery. By contrast, severe neurological impairment known as lead encephalopathy from sniffing leaded petrol occurred as more catastrophic or abrupt damage to cerebellar processes that may never fully recover. Neuroanatomical damage may not recover even with prolonged abstinence. |
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Authors:
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Kylie M Dingwall; Sheree Cairney |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Substance use & misuse Volume: 46 Suppl 1 ISSN: 1532-2491 ISO Abbreviation: Subst Use Misuse Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602153 Medline TA: Subst Use Misuse Country: England |
Other Details:
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Languages: eng Pagination: 73-83 Citation Subset: IM |
Affiliation:
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Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Northern Territory, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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