Document Detail


Recovery of the extensor digitorum longus muscle in the rat following L4 nerve sectioning.
MedLine Citation:
PMID:  8379837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to define the time course and the extent of recovery of muscle weight and tension in the extensor digitorum longus (EDL) muscle following partial denervation in nine-week-old male rats (300 to 325 g). The L4 nerve underwent unilateral sectioning while the opposite side served as a sham-operated control. The muscle weight and tension of the control and the partially denervated group were examined at two (n = 15), eight (n = 15), 12 (n = 15), and 16 (n = 15) weeks after L4 nerve sectioning. The partially denervated muscle weights as a percentage of respective controls were 58.6%, 56.1%, 68.4%, and 61.9% at two, eight, 12, and 16 weeks after L4 nerve sectioning. There was no significant difference (p > 0.05) between these percentages at the respective time intervals. The tetanic tensions compared with their respective matched controls were 14.5%, 32.8%, 50.0%, and 32.4% at these respective time intervals (p < 0.05). The muscle weight (MW) and muscle weight/body weight (MW/BW) of the partially denervated side as a percentage of its contralateral control remained unchanged throughout the duration of the experiment. The twitch tension (Pt), tetanic tension (Po), Pt/Po, and the Po/MW of the partially denervated muscle relative to its matched control increased between the second and the eighth week post-partial denervation (p < 0.05). After the eighth week post-L4 nerve sectioning, there was no further increase in these parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
G P Gutierrez; G J Herbison; P Vega; J Nasuti; E Cook; W Conlan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  74     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-10-19     Completed Date:  1993-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  922-7     Citation Subset:  AIM; IM; S    
Affiliation:
Department of Rehabilitation Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Male
Muscle Contraction
Muscle Denervation*
Muscles / innervation*
Nerve Regeneration
Rats
Rats, Sprague-Dawley
Spinal Nerves / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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