| Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma. | |
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MedLine Citation:
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PMID: 19327738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To measure corneal hysteresis (CH) in unilateral chronic primary angle-closure glaucoma (CPACG) patients to determine if it was affected by high intraocular pressure (IOP). DESIGN: Prospective interventional case series. METHODS: CH and Goldmann-correlated IOP (IOPg) were obtained with the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Dephew, New York, USA) and central corneal thickness (CCT) was measured by optical coherence tomography. Baseline CH, IOPg, and CCT were measured in 40 CPACG eyes and compared to the fellow eyes and 40 normal controls. Reduction of IOPg in CPACG eyes was achieved medically, followed by trabeculectomy and peripheral iridectomy. Measurements were repeated at 2 and 4 weeks posttherapy. RESULTS: IOPg decreased significantly from 31.55 +/- 10.48 mm Hg (mean +/- standard deviation) before therapy to 11.47 +/- 4.71 mm Hg, and CH increased significantly from 6.83 +/- 2.08 mm Hg to 9.22 +/- 1.80 mm Hg at 2 weeks, with no further changes after that. However, the CH in the treated eyes remained significantly lower compared with that of fellow and normal eyes. Before treatment, CH was negatively correlated with IOPg; however, there was no correlation after treatment. CCT was not affected by the reduced IOPg in the CPACG eyes. CONCLUSIONS: CH was significantly lower in CPACG patients, and partial recovery occurred after successful IOP-lowering therapy. Alternations affecting corneal biomechanical properties appear to occur during glaucoma development. |
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Authors:
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Lei Sun; Meixiao Shen; Jianhua Wang; Aiwu Fang; Aiqin Xu; Haizhen Fang; Fan Lu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-27 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 147 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-06-03 Revised Date: 2010-03-31 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 1061-6, 1066.e1-2 Citation Subset: AIM; IM |
Affiliation:
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School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Biomechanics Chronic Disease Combined Modality Therapy Cornea / physiopathology* Drug Therapy, Combination Elasticity / physiology* Female Glaucoma, Angle-Closure / physiopathology*, therapy Humans Intraocular Pressure / physiology* Male Middle Aged Prospective Studies Recovery of Function Tomography, Optical Coherence Tonometry, Ocular Trabeculectomy |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
| Comments/Corrections | |
Comment In:
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Am J Ophthalmol. 2010 Mar;149(3):524-5; author reply 525
[PMID:
20172077
]
Am J Ophthalmol. 2010 Apr;149(4):687-8; author reply 688 [PMID: 20346787 ] Am J Ophthalmol. 2009 Oct;148(4):623; author reply 623 [PMID: 19782799 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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