Document Detail

Recovery characteristics following antagonism of atracurium with neostigmine or edrophonium.
MedLine Citation:
PMID:  6326785     Owner:  NLM     Status:  MEDLINE    
The evoked reversal characteristics of atracurium were studied in 21 patients using edrophonium or neostigmine and a train-of-four pattern of stimulation. Reversal of residual atracurium -induced neuromuscular blockade was significantly more rapid using edrophonium compared with neostigmine. The ratio of the fourth twitch in the train-of-four to the first twitch--the T4 ratio--was significantly greater when the first twitch (T1) had recovered to 75% of control T1, using edrophonium compared with neostigmine. A T4 ratio of 0.5 was confirmed to be compatible with the reliable and safe reversal of atracurium -induced neuromuscular blockade.
R M Jones; A C Pearce; J P Williams
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  56     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-06-25     Completed Date:  1984-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  453-7     Citation Subset:  IM    
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MeSH Terms
Edrophonium / pharmacology*
Isoquinolines / antagonists & inhibitors*,  pharmacology
Muscle Contraction / drug effects
Neostigmine / pharmacology*
Neuromuscular Blocking Agents / antagonists & inhibitors*
Neuromuscular Junction / physiology
Random Allocation
Synaptic Transmission / drug effects
Time Factors
Reg. No./Substance:
0/Isoquinolines; 0/Neuromuscular Blocking Agents; 312-48-1/Edrophonium; 59-99-4/Neostigmine; 64228-79-1/Atracurium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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