| Recovery characteristics following antagonism of atracurium with neostigmine or edrophonium. | |
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MedLine Citation:
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PMID: 6326785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The evoked reversal characteristics of atracurium were studied in 21 patients using edrophonium or neostigmine and a train-of-four pattern of stimulation. Reversal of residual atracurium -induced neuromuscular blockade was significantly more rapid using edrophonium compared with neostigmine. The ratio of the fourth twitch in the train-of-four to the first twitch--the T4 ratio--was significantly greater when the first twitch (T1) had recovered to 75% of control T1, using edrophonium compared with neostigmine. A T4 ratio of 0.5 was confirmed to be compatible with the reliable and safe reversal of atracurium -induced neuromuscular blockade. |
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Authors:
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R M Jones; A C Pearce; J P Williams |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of anaesthesia Volume: 56 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-06-25 Completed Date: 1984-06-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 453-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atracurium Edrophonium / pharmacology* Humans Isoquinolines / antagonists & inhibitors*, pharmacology Muscle Contraction / drug effects Neostigmine / pharmacology* Neuromuscular Blocking Agents / antagonists & inhibitors* Neuromuscular Junction / physiology Random Allocation Synaptic Transmission / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 0/Neuromuscular Blocking Agents; 312-48-1/Edrophonium; 59-99-4/Neostigmine; 64228-79-1/Atracurium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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