Document Detail


Recovery of brain docosahexaenoate leads to recovery of spatial task performance.
MedLine Citation:
PMID:  14511107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infants fed vegetable oil-based formulas may have poorer visual function, lower cognitive scores and acquire learning tasks more slowly in comparison with those breast fed or those fed formulas supplemented with docosahexaenoate. The aim of the present study was to determine the reversibility of losses in brain function associated with the loss of brain DHA. Rats were fed very low or adequate levels of n-3 fatty acids through three generations. The n-3 fatty acid deficient animals of the F3 generation were then given an n-3 adequate diet containing alpha-linolenic and docosahexaenoic acids (DHA) at birth, weaning (3 weeks) or young adulthood (7 weeks). The spatial task performance of these animals returned to the n-3 adequate diet was then compared using the Morris water at two different ages, at 9 or 13 weeks. Our results indicate that animals repleted since birth or at weaning were able to achieve nearly the same level of brain DHA and spatial task performance as animals maintained for three generations on an n-3 adequate diet. In the case of young adult animals, the degree of DHA and behavioral performance recovery depended upon the duration of dietary repletion with substantial recovery in animals after 6 weeks but little recovery of function after two weeks. The significance of these findings is that they indicate that at least some of the adverse effects of DHA deficiency during neurodevelopment may be reversible with an n-3 fatty acid supplemented diet.
Authors:
Toru Moriguchi; Norman Salem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  87     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2003-11-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  297-309     Citation Subset:  IM    
Affiliation:
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852,USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Brain / drug effects*,  metabolism*
Brain Chemistry
Docosahexaenoic Acids / metabolism*,  pharmacology*
Escape Reaction / drug effects
Fatty Acids / analysis
Fatty Acids, Omega-3 / administration & dosage,  metabolism
Female
Food, Formulated
Male
Maze Learning / drug effects
Motor Activity / drug effects
Rats
Rats, Long-Evans
Reaction Time / drug effects
Recovery of Function / drug effects
Spatial Behavior / drug effects*
Time Factors
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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