Document Detail

Recovery after tonsillectomy in adults: a three-week follow-up study.
MedLine Citation:
PMID:  11802045     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate recovery after tonsillectomy and safety and efficacy of ketoprofen in pain treatment after discharge. STUDY DESIGN: A prospective, longitudinal study of 102 patients undergoing tonsillectomy. METHODS: All patients underwent tonsillectomy (or adenotonsillectomy) under general anesthesia. In the hospital, 77 patients received a bolus of 0.5 mg/kg ketoprofen intravenously, followed by a 3-mg/kg continuous infusion over 24 hours, and oxycodone for rescue analgesia. Twenty-five patients received normal saline and oxycodone. At discharge, all patients were prescribed ketoprofen capsules at a dose of 3 to 5 mg/kg per day for postoperative pain control at home, with paracetamol-codeine tablets for rescue analgesia. At home, the patients recorded pain and analgesic consumption each day for the first week after surgery. At 3 weeks, patients recorded the total analgesic requirement, duration of pain, all adverse events during recovery, and return to normal daily activities. RESULTS: No pre-emptive effect of ketoprofen was noticed because there was no significant difference in recovery after discharge between patients who had received ketoprofen or placebo during the first 24 hours after surgery. In the whole study group, the median of pain cessation was 11 days (range, 3-24 days) and the median of analgesic treatment was 12 days (range, 5-25 days). More than 50% of the patients needed 1 to 3 rescue analgesic doses daily during the first week after tonsillectomy. A return back to normal daily activities took place after 12 days (range, 2-24 days). Nine patients needed electrocautery to stop postoperative bleeding. No other serious adverse events occurred. CONCLUSIONS: The main problem after tonsillectomy is significant pain that can last 11 to 12 days after surgery. Ketoprofen combined with paracetamol-codeine provided sufficient analgesia for most patients at home, but because ketoprofen may cause an increase in the secondary hemorrhage rate, it should be prescribed with caution.
Aarre Salonen; Hannu Kokki; Juhani Nuutinen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  112     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-21     Completed Date:  2002-02-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-8     Citation Subset:  IM    
Department of Otorhinolaryngology, Kuopio University Hospital, FIN-70211 Kuopio, Finland.
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MeSH Terms
Acetaminophen / administration & dosage
Administration, Oral
Codeine / administration & dosage
Drug Therapy, Combination
Follow-Up Studies
Infusions, Intravenous
Ketoprofen / administration & dosage,  adverse effects
Middle Aged
Pain Measurement
Pain, Postoperative / drug therapy,  etiology
Patient Discharge
Postoperative Complications / etiology*
Prospective Studies
Reg. No./Substance:
103-90-2/Acetaminophen; 22071-15-4/Ketoprofen; 76-57-3/Codeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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