Document Detail

Recovery after anaesthesia for pulmonary surgery: desflurane, sevoflurane and isoflurane.
MedLine Citation:
PMID:  10434815     Owner:  NLM     Status:  MEDLINE    
We have studied maintenance and recovery profiles after general anaesthesia with sevoflurane, desflurane and isoflurane in 100 patients undergoing pulmonary surgery. End-tidal concentrations of anaesthetic required to maintain mean arterial pressure and heart rate within 20% of baseline values were 1.4 +/- 0.6% for sevoflurane, 3.4 +/- 0.9% for desflurane and 0.7 +/- 0.3% for isoflurane. The three anaesthetics had comparable haemodynamic effects and arterial oxygenation during one-lung ventilation. Emergence was twice as fast with desflurane than with sevoflurane or isoflurane (mean times to extubation: 8.9 (SD 5.0) min, 18.0 (17.0) min and 16.2 (11.0) min for desflurane, sevoflurane and isoflurane, respectively). Early recovery (Aldrete score, cognitive and psychomotor functions) was also more rapid after desflurane. In pulmonary surgery, desflurane, but not sevoflurane, allowed more rapid emergence and earlier recovery than isoflurane.
J Dupont; B Tavernier; Y Ghosez; L Durinck; A Thevenot; N Moktadir-Chalons; L Ruyffelaere-Moises; N Declerck; P Scherpereel
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  82     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-08-12     Completed Date:  1999-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-9     Citation Subset:  IM    
Département d'Anesthésie Réanimation Chirurgicale II, CHRU, Lille, France.
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MeSH Terms
Anesthesia Recovery Period
Anesthetics, Inhalation / pharmacology*
Blood Pressure / drug effects
Cognition / drug effects
Heart Rate / drug effects
Isoflurane / analogs & derivatives,  pharmacology
Lung / surgery*
Methyl Ethers / pharmacology
Middle Aged
Oxygen / blood
Prospective Studies
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane; 7782-44-7/Oxygen

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